PMID- 10549280
OWN - NLM
STAT- MEDLINE
DCOM- 19991126
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 4
DP  - 1999 Oct
TI  - A role for the deep orange and carnation eye color genes in lysosomal delivery in 
      Drosophila.
PG  - 479-86
AB  - Deep orange and carnation are two of the classic eye color genes in Drosophila. 
      Here, we demonstrate that Deep orange is part of a protein complex that localizes 
      to endosomal compartments. A second component of this complex is Carnation, a 
      homolog of Sec1p-like regulators of membrane fusion. Because complete loss of 
      deep orange function is lethal, the role of this complex in intracellular 
      trafficking was analyzed in deep orange mutant clones. Retinal cells devoid of 
      deep orange function completely lacked pigmentation and exhibited exaggerated 
      multivesicular structures. Furthermore, a defect in endocytic trafficking was 
      visualized in developing photoreceptor cells. These results provide direct 
      evidence that eye color mutations of the granule group also disrupt vesicular 
      trafficking to lysosomes.
FAU - Sevrioukov, E A
AU  - Sevrioukov EA
AD  - Department of Cell Biology, University of Texas Southwestern Medical Center, 
      Dallas 75235, USA.
FAU - He, J P
AU  - He JP
FAU - Moghrabi, N
AU  - Moghrabi N
FAU - Sunio, A
AU  - Sunio A
FAU - Kramer, H
AU  - Kramer H
LA  - eng
SI  - GENBANK/AF133260
GR  - R01 EY010199/EY/NEI NIH HHS/United States
GR  - EY10199/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (DOR protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Fungal Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (VPS33 protein, S cerevisiae)
RN  - 0 (Vesicular Transport Proteins)
RN  - 0 (car protein, Drosophila)
RN  - 0 (hook protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Carrier Proteins
MH  - DNA-Binding Proteins/chemistry/*genetics/*metabolism
MH  - Drosophila/*genetics
MH  - *Drosophila Proteins
MH  - Endosomes/genetics
MH  - Eye Color/*genetics
MH  - Eye Proteins/*genetics
MH  - Fluorescent Antibody Technique
MH  - Fungal Proteins/chemistry
MH  - Insect Proteins/genetics
MH  - Lysosomes/genetics
MH  - Microscopy, Fluorescence
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Photoreceptor Cells, Invertebrate/ultrastructure
MH  - *Saccharomyces cerevisiae Proteins
MH  - *Vesicular Transport Proteins
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S1097-2765(00)80199-9 [pii]
AID - 10.1016/s1097-2765(00)80199-9 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Oct;4(4):479-86. doi: 10.1016/s1097-2765(00)80199-9.