PMID- 10548725
OWN - NLM
STAT- MEDLINE
DCOM- 19991209
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 239
IP  - 2
DP  - 1999 Nov 1
TI  - Characterization of mouse peroxiredoxin I genomic DNA and its expression.
PG  - 243-50
AB  - Peroxiredoxins (Prxs) are a newly defined family of anti-oxidant proteins that
      have been implicated, via their anti-oxidant activity, in a number of cellular
      functions, including cell proliferation and differentiation, protection of other 
      proteins from oxidative damage, and intracellular signaling. We isolated genomic 
      DNA sequences of the Prx I genes from the mouse, and characterized their
      molecular genetic features. Prx I was found to form a small gene family with two 
      and three members; one functional and two pseudogenes. The Prx I-1 gene has
      splice donor/acceptor site sequences and five or six exons, whereas the Prx I-2
      clone has several structural features characteristic of a typical retroposon
      found to have ORF sequences. We analyzed the expression of pseudogenes, which
      were not expressed on the transcription levels in the investigated organs. The
      functional copy of the Prx I-1 gene was expressed abundantly in liver and kidney 
      of the adult, as well as in early developing embryos. This report, together with 
      amino acid/nucleotide sequence similarity between human and mice, provides a
      basis for speculating on an even earlier event in the evolution of the Prx I gene
      family, i.e. the Prx I gene was well conserved in human and mice via its
      anti-oxidant activity.
FAU - Lee, T H
AU  - Lee TH
AD  - Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong,
      Taejon, South Korea.
FAU - Yu, S L
AU  - Yu SL
FAU - Kim, S U
AU  - Kim SU
FAU - Lee, K K
AU  - Lee KK
FAU - Rhee, S G
AU  - Rhee SG
FAU - Yu, D Y
AU  - Yu DY
LA  - eng
SI  - GENBANK/AF157328
SI  - GENBANK/AF157329
SI  - GENBANK/AF157330
SI  - GENBANK/AF157331
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (Isoenzymes)
RN  - 0 (RNA, Messenger)
RN  - 9007-49-2 (DNA)
RN  - EC 1.11.1.- (Peroxidases)
RN  - EC 1.11.1.15 (Peroxiredoxins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cloning, Molecular
MH  - DNA/chemistry/*genetics
MH  - DNA, Complementary/chemistry/genetics
MH  - Exons
MH  - Gene Expression
MH  - Gene Expression Regulation, Developmental
MH  - Genes/genetics
MH  - Genomic Library
MH  - Introns
MH  - Isoenzymes/genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Molecular Sequence Data
MH  - Peroxidases/*genetics
MH  - Peroxiredoxins
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
MH  - Tissue Distribution
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S0378111999004138 [pii]
AID - 10.1016/s0378-1119(99)00413-8 [doi]
PST - ppublish
SO  - Gene. 1999 Nov 1;239(2):243-50. doi: 10.1016/s0378-1119(99)00413-8.