PMID- 10545595
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 8
IP  - 12
DP  - 1999 Nov
TI  - Association analysis using refined microsatellite markers localizes a
      susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to 
      the HLA-C gene.
PG  - 2165-70
AB  - The HLA-Cw6 antigen has been associated with psoriasis vulgaris despite racial
      and ethnic differences. However, it remains unclear whether it is the HLA-Cw6
      antigen itself or a closely linked, hitherto unidentified, locus that predisposes
      to the disease. Here, in order to map the susceptibility locus for psoriasis
      vulgaris precisely within the HLA class I region, 11 polymorphic microsatellite
      markers distributed throughout a 1060 kb segment surrounding the HLA-C locus were
      subjected to association analysis in Japanese psoriasis vulgaris patients.
      Statistical analyses of the distribution and deviation from Hardy-Weinberg
      equilibrium of the allelic frequency at each micro-satellite locus revealed that 
      the pathogenic gene for psoriasis vulgaris is located within a reduced interval
      of 111 kb spanning 89-200 kb telomeric of the HLA-C gene. In addition to three
      known genes, POU5F1, TCF19 and S, this 111 kb fragment contains four new,
      expressed genes identified in the course of our genomic sequencing of the entire 
      HLA class I region. Therefore, these seven genes are the potential candidates for
      susceptibility to psoriasis vulgaris.
FAU - Oka, A
AU  - Oka A
AD  - Department of Genetic Information, Tokai University School of Medicine,Bohseidai,
      Kanagawa, Japan.
FAU - Tamiya, G
AU  - Tamiya G
FAU - Tomizawa, M
AU  - Tomizawa M
FAU - Ota, M
AU  - Ota M
FAU - Katsuyama, Y
AU  - Katsuyama Y
FAU - Makino, S
AU  - Makino S
FAU - Shiina, T
AU  - Shiina T
FAU - Yoshitome, M
AU  - Yoshitome M
FAU - Iizuka, M
AU  - Iizuka M
FAU - Sasao, Y
AU  - Sasao Y
FAU - Iwashita, K
AU  - Iwashita K
FAU - Kawakubo, Y
AU  - Kawakubo Y
FAU - Sugai, J
AU  - Sugai J
FAU - Ozawa, A
AU  - Ozawa A
FAU - Ohkido, M
AU  - Ohkido M
FAU - Kimura, M
AU  - Kimura M
FAU - Bahram, S
AU  - Bahram S
FAU - Inoko, H
AU  - Inoko H
LA  - eng
SI  - GENBANK/AB029331
SI  - GENBANK/AB031479
SI  - GENBANK/AB031480
SI  - GENBANK/AB031481
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (DNA Primers)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - DNA Primers
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - *Microsatellite Repeats
MH  - Molecular Sequence Data
MH  - Psoriasis/*genetics
MH  - *Telomere
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - ddc255 [pii]
AID - 10.1093/hmg/8.12.2165 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1999 Nov;8(12):2165-70. doi: 10.1093/hmg/8.12.2165.