PMID- 10545117
OWN - NLM
STAT- MEDLINE
DCOM- 20000104
LR  - 20190515
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 21
DP  - 1999 Nov 1
TI  - The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in
      Spemann's organizer.
PG  - 6062-72
AB  - The anterior endomesoderm of the early Xenopus gastrula is a part of Spemann's
      organizer and is important for head induction. Here we describe Xblimp1, which
      encodes a zinc finger transcriptional repressor expressed in the anterior
      endomesoderm. Xblimp1 represses trunk mesoderm and induces anterior endomesoderm 
      in a cooperative manner with the pan-endodermal gene Mix.1. Furthermore, Xblimp1 
      can cooperate with the BMP inhibitor chordin to induce ectopic heads, while a
      dominant-negative Xblimp1 inhibits head formation. The head inducer cerberus is
      positively regulated by Xblimp1 and is able to rescue microcephalic embryos
      caused by dominant-negative Xblimp1. Our results indicate that Xblimp1 is
      required for anterior endomesodermal cell fate and head induction.
FAU - de Souza, F S
AU  - de Souza FS
AD  - Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im
      Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
FAU - Gawantka, V
AU  - Gawantka V
FAU - Gomez, A P
AU  - Gomez AP
FAU - Delius, H
AU  - Delius H
FAU - Ang, S L
AU  - Ang SL
FAU - Niehrs, C
AU  - Niehrs C
LA  - eng
SI  - GENBANK/AF182280
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Mix1 protein, Xenopus)
RN  - 0 (PRDM1 protein, Xenopus)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - 0 (Xenopus Proteins)
RN  - 0 (cer1 protein, Xenopus)
RN  - 93586-27-7 (chordin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone Morphogenetic Proteins/antagonists & inhibitors
MH  - Cloning, Molecular
MH  - Embryonic Induction/genetics
MH  - Gene Expression Regulation, Developmental
MH  - Glycoproteins/metabolism
MH  - Head/embryology
MH  - Homeodomain Proteins/metabolism
MH  - In Situ Hybridization
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Mesoderm/*metabolism
MH  - Microinjections
MH  - Molecular Sequence Data
MH  - Proteins/*genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Repressor Proteins/chemistry/*genetics
MH  - Sequence Alignment
MH  - Xenopus/embryology
MH  - *Xenopus Proteins
MH  - Zinc Fingers/*genetics
PMC - PMC1171671
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
AID - 10.1093/emboj/18.21.6062 [doi]
PST - ppublish
SO  - EMBO J. 1999 Nov 1;18(21):6062-72. doi: 10.1093/emboj/18.21.6062.