PMID- 10545116
OWN - NLM
STAT- MEDLINE
DCOM- 20000104
LR  - 20161019
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 21
DP  - 1999 Nov 1
TI  - The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR)
      and participates in programmed cell death.
PG  - 6050-61
AB  - NRIF (neurotrophin receptor interacting factor) is a ubiquitously expressed zinc 
      finger protein of the Kruppel family which interacts with the neurotrophin
      receptor p75(NTR). The interaction was first detected in yeast and then
      biochemically confirmed using recombinant GST-NRIF fusions and p75(NTR) expressed
      by eukaryotic cells. Transgenic mice carrying a deletion in the exon encoding the
      p75(NTR)-binding domain of NRIF display a phenotype which is strongly dependent
      upon genetic background. While at the F(2 )generation there is only limited (20%)
      embryonic lethality, in a congenic BL6 strain nrif(-/-) mice cannot survive
      beyond E12, but are viable and healthy to adulthood in the Sv129 background. The 
      involvement of NRIF in p75(NTR)/NGF-mediated developmental cell death was
      examined in the mouse embryonic neural retina. Disruption of the nrif gene leads 
      to a reduction in cell death which is quantitatively indistinguishable from that 
      observed in p75(NTR)(-/-) and ngf(-/-) mice. These results indicate that NRIF is 
      an intracellular p75(NTR)-binding protein transducing cell death signals during
      development.
FAU - Casademunt, E
AU  - Casademunt E
AD  - Department of Neurobiochemistry, Max Planck Institute of Neurobiology, D-82152
      Martinsried, Germany.
FAU - Carter, B D
AU  - Carter BD
FAU - Benzel, I
AU  - Benzel I
FAU - Frade, J M
AU  - Frade JM
FAU - Dechant, G
AU  - Dechant G
FAU - Barde, Y A
AU  - Barde YA
LA  - eng
SI  - GENBANK/AJ242914
GR  - R01NS38220/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Zfp110 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Apoptosis
MH  - Binding Sites/genetics
MH  - Carrier Proteins/chemistry/*genetics
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/metabolism
MH  - Embryonic and Fetal Development/genetics
MH  - Gene Targeting
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Protein Binding/genetics
MH  - RNA, Messenger/metabolism
MH  - Receptor, Nerve Growth Factor/*metabolism
MH  - Recombinant Fusion Proteins/metabolism
MH  - *Repressor Proteins
MH  - Retina/embryology
MH  - Transcription Factors/metabolism
MH  - Transfection
MH  - Zinc Fingers/*genetics
PMC - PMC1171670
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
AID - 10.1093/emboj/18.21.6050 [doi]
PST - ppublish
SO  - EMBO J. 1999 Nov 1;18(21):6050-61. doi: 10.1093/emboj/18.21.6050.