PMID- 10544657
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20061115
IS  - 0032-5449 (Print)
IS  - 0032-5449 (Linking)
VI  - 53
IP  - 4
DP  - 1999
TI  - [The role of vav protein in TCR-mediated signaling with MHC/peptide complexes
      leading to positive or negative selection of thymocytes].
PG  - 531-43
AB  - On the basis of recent reports we discuss the role of Vav in TCR-dependent
      signaling pathways. The Vav protein is GDP/GTP exchange factor for Rac, which
      initiates transduction of signals in JNK pathway. Upon stimulation of TCR by
      antigenic peptides, Vav associates with Zap-70 in TCR/CD3 signaling complex and
      becomes phosphorylated on Tyr-174 by tyrosine kinase Lck. The function of Vav is 
      modulated by substrates and products of PI3-kinase activated by interaction of
      CD28 on thymocytes with B7 on antigen presenting cells. The PI3-kinase substrates
      inhibit activation of Vav, while the products enhance phosphorylation and
      activation of Vav by Lck. It seems that Vav functions in key point of
      TCR-mediated signaling pathway, which is regulated by costimulatory molecule
      (CD28) necessary for negative selection. The Vav-mediated integration of signals 
      results in positive or negative selection of thymocytes.
FAU - Matuszyk, J
AU  - Matuszyk J
AD  - Laboratorium Immunologii Komorkowej, Instytutu Immunologii i Terapii
      Doswiadczalnej PAN, Wroclawiu.
FAU - Kalas, W
AU  - Kalas W
FAU - Kozicki, R
AU  - Kozicki R
FAU - Strzadala, L
AU  - Strzadala L
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Rola bialka vav w zamianie informacji o oddzialywaniach TCR z kompleksem
      MHC/peptyd na sygnaly inicjujace pozytywna lub negatywna selekcje tymocytow.
PL  - Poland
TA  - Postepy Hig Med Dosw
JT  - Postepy higieny i medycyny doswiadczalnej
JID - 0421052
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-vav)
RN  - 0 (Receptor-CD3 Complex, Antigen, T-Cell)
RN  - 0 (VAV1 protein, human)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Guanine Nucleotide Exchange Factors/metabolism
MH  - Humans
MH  - Major Histocompatibility Complex/physiology
MH  - Oncogene Proteins/*metabolism
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-vav
MH  - Receptor-CD3 Complex, Antigen, T-Cell/*metabolism
MH  - Signal Transduction
MH  - Thymus Gland/*metabolism
RF  - 30
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
PST - ppublish
SO  - Postepy Hig Med Dosw. 1999;53(4):531-43.