PMID- 10544143
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20061115
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 264
IP  - 1
DP  - 1999 Nov 10
TI  - Identification of a common site of provirus integration in radiation leukemia
      virus-induced T-cell lymphomas in mice.
PG  - 181-6
AB  - The BL/VL(3) Kaplan radiation leukemia virus (RadLV-VL(3)) is a nondefective
      retrovirus that induces T cell lymphomas in several strains of mice. By using DNA
      probes derived from RadLV/VL(3) provirus-flanking sequences cloned from the
      BL/VL(3) cell line, we identified a DNA region rearranged in 5 of 19 tumors
      analysed (25%). All proviruses were integrated in the same 5'-to-3' orientation
      in a small DNA region called Kis1 (Kaplan integration site 1). This region was
      localized on distal mouse chromosome 2 in a region not previously identified as
      important to lymphomagenesis. The cells rearranged at the Kis1 locus represent a 
      clonal subpopulation of the clonal tumor masses examined, indicating a probable
      role of Kis1 in tumor progression.
CI  - Copyright 1999 Academic Press.
FAU - Lambert, J
AU  - Lambert J
AD  - Departement des Sciences Biologiques, Universite du Quebec a Montreal, Quebec,
      H3C-3P8, Canada.
FAU - Bergeron, D
AU  - Bergeron D
FAU - Kozak, C A
AU  - Kozak CA
FAU - Rassart, E
AU  - Rassart E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - Crosses, Genetic
MH  - Lymphoma, T-Cell/*genetics/*virology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Muridae
MH  - Proviruses/*genetics
MH  - Radiation Leukemia Virus/*genetics
MH  - Restriction Mapping
MH  - Retroviridae Infections/genetics/virology
MH  - T-Lymphocytes/virology
MH  - Tumor Cells, Cultured
MH  - Tumor Virus Infections/genetics/virology
MH  - *Virus Integration
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
AID - 10.1006/viro.1999.9992 [doi]
AID - S0042-6822(99)99992-0 [pii]
PST - ppublish
SO  - Virology. 1999 Nov 10;264(1):181-6. doi: 10.1006/viro.1999.9992.