PMID- 10544019
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20080514
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 264
IP  - 3
DP  - 1999 Nov 2
TI  - A human IAP-family gene, apollon, expressed in human brain cancer cells.
PG  - 847-54
AB  - IAP is a family of protein that has baculovirus IAP repeat (BIR) domains and
      inhibits apoptosis. We found a human IAP family gene, which we named Apollon,
      encoding a huge protein (530 kDa) that contains a single BIR domain and a
      ubiquitin-conjugating enzyme domain, that is a human homolog of BRUCE. Apollon
      protein was expressed in four of six brain cancers (gliomas), and one of five
      ovarian cancers in 38 human cancer cell lines that we examined. Among the brain
      cancer cell lines, SNB-78 expressed a high level of Apollon, and this cell line
      shows resistance against various anticancer drugs. Treating SNB-78 cells with
      antisense oligonucleotide against Apollon reduced the expression of Apollon
      protein, and significantly sensitized the cells to apoptosis induced by cisplatin
      and camptothecin. These results suggest that Apollon protects SNB-78 cells from
      undergoing apoptosis and, at least in part, plays a role in tumorigenesis and
      drug resistance of this cell line.
CI  - Copyright 1999 Academic Press.
FAU - Chen, Z
AU  - Chen Z
AD  - Institute of Molecular Biosciences, University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku,
      Tokyo, 113-0032, Japan.
FAU - Naito, M
AU  - Naito M
FAU - Hori, S
AU  - Hori S
FAU - Mashima, T
AU  - Mashima T
FAU - Yamori, T
AU  - Yamori T
FAU - Tsuruo, T
AU  - Tsuruo T
LA  - eng
SI  - GENBANK/AF265555
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (BIRC6 protein, human)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteins)
RN  - 0 (X-Linked Inhibitor of Apoptosis Protein)
RN  - 0 (XIAP protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Brain Neoplasms/*genetics
MH  - DNA, Neoplasm/genetics
MH  - *Gene Expression Regulation, Neoplastic
MH  - Glioma/*genetics
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*genetics
MH  - Proteins/*genetics
MH  - Tumor Cells, Cultured
MH  - X-Linked Inhibitor of Apoptosis Protein
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
AID - 10.1006/bbrc.1999.1585 [doi]
AID - S0006-291X(99)91585-1 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Nov 2;264(3):847-54. doi:
      10.1006/bbrc.1999.1585.