PMID- 10544010
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20171116
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 264
IP  - 3
DP  - 1999 Nov 2
TI  - Identification and gene structure of a novel human PLZF-related transcription
      factor gene, TZFP.
PG  - 789-95
AB  - A novel cDNA clone was identified through yeast two-hybrid experiments. Following
      cross-examination between the cDNA clones, EST clones, and the cosmid clone, we
      could digitally assemble a new zinc finger transcription factor gene. This
      predicted gene has a cDNA size of about 1960 bp and is translated into a
      487-amino-acid protein. According to database analysis, this gene contains three 
      C2H2 zinc finger motifs and is highly related to human PLZF (promyelocytic
      leukemia zinc finger protein). The full-length coding region of the gene was
      isolated, and its sequences were confirmed by DNA sequencing. Interestingly, one 
      splicing variant lacking exon III was also identified. Northern blot analysis
      revealed that this gene is mainly expressed in human testis. In conclusion, we
      have identified a new member of the PLZF zinc finger protein family, the testis
      zinc finger protein (TZFP), which is mainly expressed in testis tissue.
CI  - Copyright 1999 Academic Press.
FAU - Lin, W
AU  - Lin W
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
      wenlin@ibms.sinica.edu.tw
FAU - Lai, C H
AU  - Lai CH
FAU - Tang, C J
AU  - Tang CJ
FAU - Huang, C J
AU  - Huang CJ
FAU - Tang, T K
AU  - Tang TK
LA  - eng
SI  - GENBANK/AF130255
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Promyelocytic Leukemia Zinc Finger Protein)
RN  - 0 (Transcription Factors)
RN  - 147855-37-6 (ZBTB16 protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary/*genetics/isolation & purification
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Male
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Promyelocytic Leukemia Zinc Finger Protein
MH  - Sequence Alignment
MH  - Testis
MH  - Transcription Factors/*genetics
MH  - Zinc Fingers/genetics
EDAT- 1999/11/02 00:00
MHDA- 1999/11/02 00:01
CRDT- 1999/11/02 00:00
PHST- 1999/11/02 00:00 [pubmed]
PHST- 1999/11/02 00:01 [medline]
PHST- 1999/11/02 00:00 [entrez]
AID - 10.1006/bbrc.1999.1594 [doi]
AID - S0006291X99915942 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Nov 2;264(3):789-95. doi:
      10.1006/bbrc.1999.1594.