PMID- 10543676
OWN - NLM
STAT- MEDLINE
DCOM- 19991110
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 354
IP  - 9188
DP  - 1999 Oct 23
TI  - Directed pharmacological therapy of ambiguous genitalia due to an androgen
      receptor gene mutation.
PG  - 1444-5
AB  - We report a 46,XY infant with an M807T mutation in his androgen receptor that
      abrogated cellular responses to testosterone, but not to dihydrotestosterone
      (DHT), resulting in ambiguous genitalia. Treatment with a topical DHT gel
      restored male genital development allowing the infant to be reared in accordance 
      with his chromosomal sex.
FAU - Ong, Y C
AU  - Ong YC
FAU - Wong, H B
AU  - Wong HB
FAU - Adaikan, G
AU  - Adaikan G
FAU - Yong, E L
AU  - Yong EL
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Receptors, Androgen)
RN  - 08J2K08A3Y (Dihydrotestosterone)
SB  - IM
MH  - Administration, Topical
MH  - Androgen-Insensitivity Syndrome/diagnosis/*drug therapy/genetics
MH  - Dihydrotestosterone/*therapeutic use
MH  - Drug Monitoring/*methods
MH  - Gonadal Steroid Hormones/*therapeutic use
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Receptors, Androgen/drug effects
MH  - Transcriptional Activation/drug effects
EDAT- 1999/10/30 00:00
MHDA- 1999/10/30 00:01
CRDT- 1999/10/30 00:00
PHST- 1999/10/30 00:00 [pubmed]
PHST- 1999/10/30 00:01 [medline]
PHST- 1999/10/30 00:00 [entrez]
AID - S0140673699032055 [pii]
AID - 10.1016/s0140-6736(99)03205-5 [doi]
PST - ppublish
SO  - Lancet. 1999 Oct 23;354(9188):1444-5. doi: 10.1016/s0140-6736(99)03205-5.