PMID- 10542332
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1447
IP  - 2-3
DP  - 1999 Oct 28
TI  - Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor 
      rho subunit genes: GABRR1, GABRR2 and GABRR3.
PG  - 307-12
AB  - GABA(C) receptors mediate rapid inhibitory neurotransmission in retina. We have
      mapped, in detail, the human genes which encode the three polypeptides that
      comprise this receptor: rho1 (GABRR1), rho2 (GABRR2) and rho3 (GABRR3). We show
      that GABRR1 and GABRR2 are located close together, in a region of chromosome 6q
      that contains loci for inherited disorders of the eye, but that GABRR3 maps to
      chromosome 3q11-q13.3. Our mapping data suggest that the rho polypeptide genes,
      which are thought to share a common ancestor with GABA(A) receptor subunit genes,
      diverged at an early stage in the evolution of this gene family.
FAU - Bailey, M E
AU  - Bailey ME
AD  - Division of Molecular Genetics, Institute of Biomedical and Life Sciences,
      University of Glasgow, Anderson College, 56 Dumbarton Road, Glasgow, UK.
      mbailey@molgen.gla.ac.uk
FAU - Albrecht, B E
AU  - Albrecht BE
FAU - Johnson, K J
AU  - Johnson KJ
FAU - Darlison, M G
AU  - Darlison MG
LA  - eng
SI  - GENBANK/Y18994
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (GABA type B receptor, subunit 1)
RN  - 0 (GABRR2 protein, human)
RN  - 0 (Receptors, GABA)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, GABA-B)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - Genetic Linkage
MH  - Humans
MH  - Molecular Sequence Data
MH  - Receptors, GABA/*genetics
MH  - Receptors, GABA-A
MH  - *Receptors, GABA-B
EDAT- 1999/11/05 00:00
MHDA- 1999/11/05 00:01
CRDT- 1999/11/05 00:00
PHST- 1999/11/05 00:00 [pubmed]
PHST- 1999/11/05 00:01 [medline]
PHST- 1999/11/05 00:00 [entrez]
AID - S0167-4781(99)00167-0 [pii]
AID - 10.1016/s0167-4781(99)00167-0 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Oct 28;1447(2-3):307-12. doi:
      10.1016/s0167-4781(99)00167-0.