PMID- 10542133
OWN - NLM
STAT- MEDLINE
DCOM- 20000829
LR  - 20081121
IS  - 1522-4724 (Print)
IS  - 1522-4724 (Linking)
VI  - 2
IP  - 2
DP  - 1999 Aug
TI  - Molecular characterization and genomic mapping of human IPM 200, a second member 
      of a novel family of proteoglycans.
PG  - 103-10
AB  - We report herein the characterization of the cDNA for a novel human chondroitin
      sulfate proteoglycan, designated IPM 200, and the chromosomal location of its
      gene, designated IMPG2. IPM 200 was isolated from the retinal interphotoreceptor 
      matrix, a unique extracellular matrix that occupies the subretinal space between 
      the apices of the retinal pigment epithelium and the neural retina. The cDNA
      contains an open reading frame of 3,726 bp that codes for a core protein with a
      deduced molecular weight of 138.5 kDa. The deduced IPM 200 core protein contains 
      a putative transmembrane domain, two EGF-like repeats, numerous N- and O-linked
      glycosylation consensus sequences and one consensus sequence for
      glycosaminoglycan attachment. IMPG2 maps to human chromosome 3q12.2-12.3. Based
      on homologies within their amino acid sequences we propose that IPM 200 and a
      previously described human proteoglycan, IPM 150, form a new family of
      extracellular matrix glycoconjugates.
FAU - Kuehn, M H
AU  - Kuehn MH
AD  - Department of Ophthalmology and Visual Sciences, University of Iowa Center for
      Macular Degeneration, Iowa City 52240, USA.
FAU - Hageman, G S
AU  - Hageman GS
LA  - eng
SI  - GENBANK/AF047492
GR  - EY06463/EY/NEI NIH HHS/United States
GR  - EY11515/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol Res Commun
JT  - Molecular cell biology research communications : MCBRC
JID - 100889076
RN  - 0 (IMPG2 protein, human)
RN  - 0 (Proteoglycans)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - Cloning, Molecular
MH  - Humans
MH  - Molecular Sequence Data
MH  - *Ocular Physiological Phenomena
MH  - Proteoglycans/*genetics/metabolism
MH  - Retina/physiology
MH  - Sequence Analysis, Protein
MH  - Sequence Homology, Amino Acid
EDAT- 1999/11/05 08:00
MHDA- 2000/09/02 11:01
CRDT- 1999/11/05 08:00
PHST- 1999/11/05 08:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 1999/11/05 08:00 [entrez]
AID - 10.1006/mcbr.1999.0161 [doi]
AID - S1522472499901617 [pii]
PST - ppublish
SO  - Mol Cell Biol Res Commun. 1999 Aug;2(2):103-10. doi: 10.1006/mcbr.1999.0161.