PMID- 10541802
OWN - NLM
STAT- MEDLINE
DCOM- 19991119
LR  - 20190831
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 50
IP  - 1-2
DP  - 1999 Oct
TI  - Structure and expression of the mouse homologue of the XK gene.
PG  - 16-21
AB  - The human Kx blood group antigen is carried by a 37,000 M(r) apparent molecular
      mass membrane polypeptide which is deficient in rare individuals with the McLeod 
      syndrome. The X-linked human XK gene is transcribed in many tissues including
      adult skeletal muscle and brain, sieges of disorders observed in McLeod syndrome.
      We report here the cloning of the orthologous mouse XK mRNA. Comparison of XK
      from human and mouse revealed 80% sequence similarity at the amino acid level.
      The mouse XK gene is organized in two exons and is expressed in many tissues, but
      its expression pattern is slightly different from that of the human gene. The
      presence in mouse erythrocyte membrane of a 43,000 M(r) Kx-related protein was
      demonstrated by immunoblotting with a rabbit antiserum directed against the human
      protein. With non-reduced samples, a 140,000 M(r) species was detected instead of
      the 43,000 M(r) protein, suggesting that, as demonstrated in the Kx polypeptide
      might be complexed with another protein in mouse red cells, presumably the
      homologue of the human Kell protein of 93,000 M(r).
FAU - Collec, E
AU  - Collec E
AD  - INSERM U76, Institut National de la Transfusion Sanguine, 6 rue Alexandre
      Cabanel, 75015 Paris, France.
FAU - Colin, Y
AU  - Colin Y
FAU - Carbonnet, F
AU  - Carbonnet F
FAU - Hattab, C
AU  - Hattab C
FAU - Bertrand, O
AU  - Bertrand O
FAU - Cartron, J P
AU  - Cartron JP
FAU - Kim, C L
AU  - Kim CL
LA  - eng
SI  - GENBANK/AF155511
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Amino Acid Transport Systems, Neutral)
RN  - 0 (Blood Group Antigens)
RN  - 0 (Carrier Proteins)
RN  - 0 (Kell Blood-Group System)
RN  - 0 (Membrane Proteins)
RN  - 0 (Xkh protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Amino Acid Transport Systems, Neutral
MH  - Animals
MH  - Blood Group Antigens/*genetics
MH  - Carrier Proteins/*genetics/metabolism
MH  - Erythrocyte Membrane/chemistry
MH  - Gene Library
MH  - Kell Blood-Group System
MH  - Membrane Proteins/*genetics/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal
MH  - Protein Binding
MH  - Tissue Distribution
EDAT- 1999/10/29 00:00
MHDA- 1999/10/29 00:01
CRDT- 1999/10/29 00:00
PHST- 1999/10/29 00:00 [pubmed]
PHST- 1999/10/29 00:01 [medline]
PHST- 1999/10/29 00:00 [entrez]
AID - 90500016.251 [pii]
AID - 10.1007/s002510050681 [doi]
PST - ppublish
SO  - Immunogenetics. 1999 Oct;50(1-2):16-21. doi: 10.1007/s002510050681.