PMID- 10541800
OWN - NLM
STAT- MEDLINE
DCOM- 19991119
LR  - 20190831
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 50
IP  - 1-2
DP  - 1999 Oct
TI  - Cloning of a new lectin-like receptor expressed on human NK cells.
PG  - 1-7
AB  - Natural killer (NK) cells constitute the third major population of lymphocytes.
      They possess the inherent capacity to kill various tumor and virally infected
      cells and mediate the rejection of bone-marrow grafts in lethally irradiated
      animals. A large family of NK cell receptors belong to the C-type lectin
      superfamily and are localized to the NK gene complex on Chromosome (Chr) 6 in the
      mouse and Chr 12 in the human. Genes in the NK gene complex encode type II
      receptors and examples include the families of NKR-P1, Ly-49, and NKG2 receptors.
      Examples of other C-type lectin-like NK cell receptors that occur as individual
      genes are CD94, CD69, and AICL. Here we report the molecular characterization and
      chromosomal mapping of a human lectin-like transcript (LLT1) expressed on NK, T, 
      and B cells and localized to the NK gene complex within 100 kilobases of CD69.
      The cDNA encodes a predicted protein of 191 amino acid residues with a
      transmembrane domain near the N-terminus and an extracellular domain of 132 amino
      acid residues with similarity to the carbohydrate recognition domain of C-type
      lectins. The predicted protein of LLT1 shows 59 and 56% similarity to AICL and
      CD69, respectively. The predicted protein does not contain any intracellular ITIM
      motifs, suggesting that LLT1 may be involved in mediating activation signals.
FAU - Boles, K S
AU  - Boles KS
AD  - Department of Molecular Biology and Immunology, University of North Texas Health 
      Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699, USA.
FAU - Barten, R
AU  - Barten R
FAU - Kumaresan, P R
AU  - Kumaresan PR
FAU - Trowsdale, J
AU  - Trowsdale J
FAU - Mathew, P A
AU  - Mathew PA
LA  - eng
SI  - GENBANK/AF133299
GR  - P01 AI 38938/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (CLEC2D protein, human)
RN  - 0 (Lectins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 12
MH  - Cloning, Molecular
MH  - Humans
MH  - *Killer Cells, Natural
MH  - Lectins/*genetics
MH  - *Lectins, C-Type
MH  - *Lymphocytes
MH  - Molecular Sequence Data
MH  - Receptors, Cell Surface/*genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/10/29 00:00
MHDA- 1999/10/29 00:01
CRDT- 1999/10/29 00:00
PHST- 1999/10/29 00:00 [pubmed]
PHST- 1999/10/29 00:01 [medline]
PHST- 1999/10/29 00:00 [entrez]
AID - 90500001.251 [pii]
AID - 10.1007/s002510050679 [doi]
PST - ppublish
SO  - Immunogenetics. 1999 Oct;50(1-2):1-7. doi: 10.1007/s002510050679.