PMID- 10537072
OWN - NLM
STAT- MEDLINE
DCOM- 19991105
LR  - 20071115
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 73
IP  - 5
DP  - 1999 Nov
TI  - Distribution and intracellular localization of a mouse homologue of
      Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system.
PG  - 2119-29
AB  - Ca2+/calmodulin-dependent protein kinases (CaMKs) are believed to play important 
      roles in the development and function of the nervous system. We report here the
      identification and expression of mouse CaMKIbeta (mCaMKIbeta), in particular
      mCaMKIbeta2, an isoform of mCaMKIbeta. During embryogenesis, the mCaMKIbeta2 gene
      is expressed mainly in the nervous system, including brain, spinal cord,
      trigeminal ganglion, and retina. Within the CNS, the expression of mCaMKIbeta2 is
      detected in the mantle zone, but not in the ventricular zone, suggesting its
      possible involvement in the differentiation of neurons. In the adult brain,
      mCaMKIbeta2 transcripts are detected at high levels in the anterior olfactory
      nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis,
      hippocampal pyramidal cells, dentate granule cells, amygdala, hypothalamic
      nuclei, parabrachial nucleus, and nucleus of the solitary tract. The distinct
      gene expression pattern suggests that mCaMKIbeta2 may also be involved in
      different mature neuronal functions from other CaMKs. In addition, mCaMKI/beta2
      proteins are localized to the cytoplasm and nuclei, but not to nucleoli,
      suggesting that mCaMKIbeta2 proteins might be involved in the cytoplasmic and
      nuclear signal transduction of the nervous system.
FAU - Ueda, T
AU  - Ueda T
AD  - Department of Biochemistry, Kobe University, School of Medicine, Japan.
FAU - Sakagami, H
AU  - Sakagami H
FAU - Abe, K
AU  - Abe K
FAU - Oishi, I
AU  - Oishi I
FAU - Maruo, A
AU  - Maruo A
FAU - Kondo, H
AU  - Kondo H
FAU - Terashima, T
AU  - Terashima T
FAU - Ichihashi, M
AU  - Ichihashi M
FAU - Yamamura, H
AU  - Yamamura H
FAU - Minami, Y
AU  - Minami Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (DNA, Complementary)
RN  - 0 (Isoenzymes)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 1)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.17 (Camk1 protein, mouse)
RN  - EC 2.7.11.17 (Camk1 protein, rat)
RN  - EC 2.7.11.17 (Pnck protein, mouse)
RN  - EC 2.7.11.17 (Pnck protein, rat)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/enzymology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 1
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*analysis/chemistry/genetics
MH  - Cell Nucleus/enzymology
MH  - Cloning, Molecular
MH  - Cytoplasm/enzymology
MH  - DNA, Complementary/chemistry/genetics
MH  - Isoenzymes/*analysis/chemistry/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nervous System/*enzymology/growth & development
MH  - PC12 Cells
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Retina/enzymology
MH  - Spinal Cord/enzymology
MH  - Tissue Distribution
MH  - Transfection
MH  - Trigeminal Ganglion/enzymology
EDAT- 1999/10/28 00:00
MHDA- 1999/10/28 00:01
CRDT- 1999/10/28 00:00
PHST- 1999/10/28 00:00 [pubmed]
PHST- 1999/10/28 00:01 [medline]
PHST- 1999/10/28 00:00 [entrez]
PST - ppublish
SO  - J Neurochem. 1999 Nov;73(5):2119-29.