PMID- 10536234
OWN - NLM
STAT- MEDLINE
DCOM- 19991228
LR  - 20190831
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 117
IP  - 1
DP  - 1999 Oct 20
TI  - Developmental expression of voltage-gated potassium channel beta subunits.
PG  - 71-80
AB  - Expression of potassium channel beta subunits (Kvbeta) was determined in the
      developing mouse CNS using an antiserum against an amino acid sequence present in
      the C-terminus of Kvbeta1, Kvbeta2, and Kvbeta3. Using the anti-Kvbeta antiserum,
      we determined that Kvbeta expression is restricted to the spinal cord and dorsal 
      root ganglia in the embryonic CNS. At birth, Kvbeta expression is detected in
      brainstem and midbrain nuclei, but was not detected in the hippocampus,
      cerebellum or cerebral cortex. During the first postnatal week, Kvbeta expression
      is present in hippocampal and cortical pyramidal cells and in cerebellar Purkinje
      cells. Expression of Kvbeta subunits reaches adult levels by the third postnatal 
      week in all of the brain regions examined. A rabbit antiserum directed against a 
      unique peptide sequence in the N-terminus of the Kvbeta1 protein demonstrates
      that this subunit displays a novel expression pattern in the developing mouse
      brain. Kvbeta1 expression is high at birth in all brain regions examined and
      decreases with age. In contrast, Kvbeta2 expression is low at birth and increases
      with age to reach adult levels by the third postnatal week. These findings
      support the notion that the differential regulation of distinct potassium channel
      beta subunits, in the developing mouse nervous system, may confer the functional 
      diversity required to mediate both neuronal survival and maturation.
FAU - Downen, M
AU  - Downen M
AD  - Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park
      Ave., Bronx, NY 10461, USA.
FAU - Belkowski, S
AU  - Belkowski S
FAU - Knowles, H
AU  - Knowles H
FAU - Cardillo, M
AU  - Cardillo M
FAU - Prystowsky, M B
AU  - Prystowsky MB
LA  - eng
GR  - R01 MH51327/MH/NIMH NIH HHS/United States
GR  - R29 NS37391/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Immune Sera)
RN  - 0 (Kcnab1 protein, mouse)
RN  - 0 (Large-Conductance Calcium-Activated Potassium Channel beta Subunits)
RN  - 0 (Potassium Channels)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Blotting, Western
MH  - Cell Nucleus/metabolism
MH  - Central Nervous System/cytology/embryology/*growth & development/*metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Immune Sera
MH  - Immunohistochemistry
MH  - Large-Conductance Calcium-Activated Potassium Channel beta Subunits
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Weight
MH  - Potassium Channels/*chemistry/*metabolism
MH  - Time Factors
EDAT- 1999/10/28 00:00
MHDA- 1999/10/28 00:01
CRDT- 1999/10/28 00:00
PHST- 1999/10/28 00:00 [pubmed]
PHST- 1999/10/28 00:01 [medline]
PHST- 1999/10/28 00:00 [entrez]
AID - S0165380699001005 [pii]
AID - 10.1016/s0165-3806(99)00100-5 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1999 Oct 20;117(1):71-80. doi:
      10.1016/s0165-3806(99)00100-5.