PMID- 10536053
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20071114
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 216
IP  - 2
DP  - 1999 Oct
TI  - Transitory expression of the A2b adenosine receptor during implantation chamber
      development.
PG  - 127-36
AB  - Adenosine is a short-range signal molecule that surges in the mouse uterus
      immediately after blastocyst implantation (Blackburn et al. [1992] Dev. Dyn.
      194:155-168). The present study has investigated patterns of uterine adenosine
      receptor expression during early post-implantation development. Strong expression
      of the A2b adenosine receptor was observed. Utilizing northern blot analysis, in 
      situ hybridization, and immunostaining, the source of expression was mapped to
      the primary and secondary decidua of the antimesometrial region, between days 4-8
      of gestation. Distribution of the A2b receptor protein followed that of the
      corresponding transcript by about one gestational day and reflected the dynamics 
      of antimesometrial tissue organization during implantation chamber development.
      Uterine adenosine surges to levels sufficient for A2b receptor engagement during 
      a defined period (i.e., days 4-6) after blastocyst implantation. Decidual A2b
      receptor expression thus defines a transitory window of murine gestation that
      corresponds to a period of human gestation encompassing most spontaneous
      pregnancy losses. Because adenosine receptors are sensitive to metabolically
      stable adenosine analogues, their differential expression during implantation
      chamber development may hold therapeutic potential in the prevention of early
      pregnancy loss. Dev Dyn 1999;216:127-136.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Blackburn, M R
AU  - Blackburn MR
AD  - Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College,
      Philadelphia, Pennsyvlania 19107, USA.
FAU - Wubah, J A
AU  - Wubah JA
FAU - Chunn, J L
AU  - Chunn JL
FAU - Thompson, L F
AU  - Thompson LF
FAU - Knudsen, T B
AU  - Knudsen TB
LA  - eng
GR  - AI18220/AI/NIAID NIH HHS/United States
GR  - AI43572/AI/NIAID NIH HHS/United States
GR  - HD30302/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of
      Anatomists
JID - 9201927
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Adenosine A2B)
RN  - 0 (Receptors, Purinergic P1)
RN  - 35920-39-9 (Adenosine-5'-(N-ethylcarboxamide))
SB  - IM
MH  - Adenosine-5'-(N-ethylcarboxamide)/metabolism
MH  - Animals
MH  - Binding Sites
MH  - Blotting, Northern
MH  - Embryo Implantation/*physiology
MH  - Female
MH  - Gene Expression Regulation
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Parity
MH  - Pregnancy
MH  - RNA, Messenger/analysis
MH  - Receptor, Adenosine A2B
MH  - Receptors, Purinergic P1/genetics/*metabolism
MH  - Uterus/*metabolism
EDAT- 1999/10/27 00:00
MHDA- 1999/10/27 00:01
CRDT- 1999/10/27 00:00
PHST- 1999/10/27 00:00 [pubmed]
PHST- 1999/10/27 00:01 [medline]
PHST- 1999/10/27 00:00 [entrez]
AID - 10.1002/(SICI)1097-0177(199910)216:2<127::AID-DVDY4>3.0.CO;2-C [pii]
AID - 10.1002/(SICI)1097-0177(199910)216:2<127::AID-DVDY4>3.0.CO;2-C [doi]
PST - ppublish
SO  - Dev Dyn. 1999 Oct;216(2):127-36. doi:
      10.1002/(SICI)1097-0177(199910)216:2<127::AID-DVDY4>3.0.CO;2-C.