PMID- 10535980
OWN - NLM
STAT- MEDLINE
DCOM- 19991210
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 22
DP  - 1999 Oct 26
TI  - LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell
      death.
PG  - 12667-72
AB  - Programmed cell death regulates a number of biological phenomena, and the
      apoptotic signal must itself be tightly controlled to avoid inappropriate cell
      death. We established a genetic screen to search for molecules that inhibit the
      apoptotic signal from the Fas receptor. Here we report the isolation of a gene,
      LFG, that protects cells uniquely from Fas but not from the mechanistically
      related tumor necrosis factor alpha death signal. LFG is widely distributed, but 
      remarkably is highly expressed in the hippocampus. LFG can bind to the Fas
      receptor, but does not regulate Fas expression or interfere with binding of an
      agonist antibody. Furthermore LFG does not inhibit binding of FADD to Fas.
FAU - Somia, N V
AU  - Somia NV
AD  - The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La
      Jolla, CA 92037, USA.
FAU - Schmitt, M J
AU  - Schmitt MJ
FAU - Vetter, D E
AU  - Vetter DE
FAU - Van Antwerp, D
AU  - Van Antwerp D
FAU - Heinemann, S F
AU  - Heinemann SF
FAU - Verma, I M
AU  - Verma IM
LA  - eng
GR  - AG10435/AG/NIA NIH HHS/United States
GR  - CA44360/CA/NCI NIH HHS/United States
GR  - P01 AG010435/AG/NIA NIH HHS/United States
GR  - R01 HL053670/HL/NHLBI NIH HHS/United States
GR  - HL3670/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antigens, CD)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (FAIM2 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, CD/physiology
MH  - Apoptosis/*genetics
MH  - Apoptosis Regulatory Proteins
MH  - Base Sequence
MH  - Blotting, Western
MH  - Carrier Proteins/*genetics
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA Primers
MH  - Down-Regulation
MH  - Fluorescent Antibody Technique
MH  - HeLa Cells
MH  - Humans
MH  - Membrane Proteins
MH  - Molecular Sequence Data
MH  - Precipitin Tests
MH  - Receptors, Tumor Necrosis Factor/physiology
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Sequence Homology, Amino Acid
MH  - fas Receptor/*physiology
PMC - PMC23041
EDAT- 1999/10/27 00:00
MHDA- 1999/10/27 00:01
CRDT- 1999/10/27 00:00
PHST- 1999/10/27 00:00 [pubmed]
PHST- 1999/10/27 00:01 [medline]
PHST- 1999/10/27 00:00 [entrez]
AID - 10.1073/pnas.96.22.12667 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12667-72. doi:
      10.1073/pnas.96.22.12667.