PMID- 10535959
OWN - NLM
STAT- MEDLINE
DCOM- 19991210
LR  - 20190613
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 22
DP  - 1999 Oct 26
TI  - Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.
PG  - 12548-52
AB  - Wnt and its intracellular effector beta-catenin regulate developmental and
      oncogenic processes. Using expression cloning to identify novel components of the
      Wnt pathway, we isolated casein kinase Iepsilon (CKIepsilon). CKIepsilon mimicked
      Wnt in inducing a secondary axis in Xenopus, stabilizing beta-catenin, and
      stimulating gene transcription in cells. Inhibition of endogenous CKIepsilon by
      kinase-defective CKIepsilon or CKIepsilon antisense-oligonucleotides attenuated
      Wnt signaling. CKIepsilon was in a complex with axin and other downstream
      components of the Wnt pathway, including Dishevelled. CKIepsilon appears to be a 
      positive regulator of the pathway and a link between upstream signals and the
      complexes that regulate beta-catenin.
FAU - Sakanaka, C
AU  - Sakanaka C
AD  - Chiron Corporation, Emeryville, CA 94608, USA.
FAU - Leong, P
AU  - Leong P
FAU - Xu, L
AU  - Xu L
FAU - Harrison, S D
AU  - Harrison SD
FAU - Williams, L T
AU  - Williams LT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (CTNNB1 protein, Xenopus)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (CTNNB1 protein, mouse)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Wnt Proteins)
RN  - 0 (Xenopus Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (beta Catenin)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Casein Kinases)
SB  - IM
MH  - Animals
MH  - Casein Kinases
MH  - Cell Line
MH  - Cytoskeletal Proteins/*metabolism
MH  - Humans
MH  - Mice
MH  - Protein Kinases/*metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Signal Transduction
MH  - *Trans-Activators
MH  - Transcription, Genetic
MH  - Wnt Proteins
MH  - Xenopus
MH  - Xenopus Proteins
MH  - *Zebrafish Proteins
MH  - beta Catenin
PMC - PMC22983
EDAT- 1999/10/27 00:00
MHDA- 1999/10/27 00:01
CRDT- 1999/10/27 00:00
PHST- 1999/10/27 00:00 [pubmed]
PHST- 1999/10/27 00:01 [medline]
PHST- 1999/10/27 00:00 [entrez]
AID - 10.1073/pnas.96.22.12548 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12548-52. doi:
      10.1073/pnas.96.22.12548.