PMID- 10534406
OWN - NLM
STAT- MEDLINE
DCOM- 19991209
LR  - 20220310
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 61
IP  - 2
DP  - 1999 Oct 15
TI  - Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic
      organization, localization to chromosomal bands 1p34-p35, and expression.
PG  - 210-8
AB  - We report the cloning and characterization of the human eukaryotic protein
      translation initiation factor EIF2C1 gene. The human EIF2C1 gene consists of 19
      exons and 18 introns that span a region of almost 50 kb. It is located on the
      short arm of chromosome 1 in the region 1p34-p35. This genomic region is
      frequently lost in human cancers such as Wilms tumors, neuroblastoma, and
      carcinomas of the breast, liver, and colon. The human EIF2C1 gene is ubiquitously
      expressed at low to medium levels. Differential polyadenylation and splicing
      result in a complex transcriptional pattern. The cDNA sequence is 7478 bp long
      and contains an extremely large 3' untranslated region of 4799 bp with multiple, 
      short repeated segments composed of mono-, tri-, or quattronucleotides
      interspersed throughout. The human EIF2C1 gene belongs to a multigene family in
      human. It is highly conserved during evolution, sharing about 90% identity with
      rabbit eIF2C and 70% identity with plant AGO1 at the amino acid level. These
      facts suggest that human EIF2C1 might play an important physiological role.
CI  - Copyright 1999 Academic Press.
FAU - Koesters, R
AU  - Koesters R
AD  - Institute of Clinical Pathology, Department of Pathology, University Hospital of 
      Zurich, Schmelzbergstrasse 12, Zurich, 8091, Switzerland.
      R.Koesters@dkfz-heidelberg.de
FAU - Adams, V
AU  - Adams V
FAU - Betts, D
AU  - Betts D
FAU - Moos, R
AU  - Moos R
FAU - Schmid, M
AU  - Schmid M
FAU - Siermann, A
AU  - Siermann A
FAU - Hassam, S
AU  - Hassam S
FAU - Weitz, S
AU  - Weitz S
FAU - Lichter, P
AU  - Lichter P
FAU - Heitz, P U
AU  - Heitz PU
FAU - von Knebel Doeberitz, M
AU  - von Knebel Doeberitz M
FAU - Briner, J
AU  - Briner J
LA  - eng
SI  - GENBANK/AF093097
SI  - GENBANK/AF121255
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (AGO1 protein, human)
RN  - 0 (Argonaute Proteins)
RN  - 0 (Eukaryotic Initiation Factors)
RN  - 0 (Peptide Initiation Factors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Argonaute Proteins
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - *Eukaryotic Initiation Factors
MH  - Female
MH  - Fetus/metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Peptide Initiation Factors/*genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Sequence Alignment
MH  - Transcription, Genetic
EDAT- 1999/10/27 00:00
MHDA- 1999/10/27 00:01
CRDT- 1999/10/27 00:00
PHST- 1999/10/27 00:00 [pubmed]
PHST- 1999/10/27 00:01 [medline]
PHST- 1999/10/27 00:00 [entrez]
AID - 10.1006/geno.1999.5951 [doi]
AID - S0888-7543(99)95951-7 [pii]
PST - ppublish
SO  - Genomics. 1999 Oct 15;61(2):210-8. doi: 10.1006/geno.1999.5951.