PMID- 10533048
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20191231
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 58
IP  - 4
DP  - 1999 Nov 15
TI  - KIAA0369, doublecortin-like kinase, is expressed during brain development.
PG  - 567-75
AB  - During embryonic development, the cerebral cortex attains its characteristic
      adult laminated structure. The finding that X-linked lissencephaly patients
      harbor mutations in the doublecortin gene implicated this gene product in the
      process of corticogenesis. An autosomal human gene, KIAA0369, with a high level
      of similarity to doublecortin, has been cloned from human adult brain. This gene 
      product contains a kinase domain in addition to a doublecortin-like domain. In
      order to evaluate whether this doublecortin-like kinase also plays a role during 
      brain development, we cloned and studied the expression pattern of the mouse
      homolog. Three cDNA products of this gene were cloned: one, doublecortin-like
      kinase, the second containing only the doublecortin-like region, and the third
      containing only the kinase domain, a homolog of the previously cloned rat CPG16
      gene. We studied doublecortin-like kinase expression in mouse using Northern blot
      analysis, in situ hybridization, and Western blot analysis, and conclude that
      doublecortin-like kinase is expressed in multiple regions of embryonic brain
      including the developing cerebral cortex.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Burgess, H A
AU  - Burgess HA
AD  - Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot,
      Israel.
FAU - Martinez, S
AU  - Martinez S
FAU - Reiner, O
AU  - Reiner O
LA  - eng
SI  - GENBANK/AF155819
SI  - GENBANK/AF155820
SI  - GENBANK/AF155821
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA Probes)
RN  - EC 2.7.1.- (Dcamkl1 protein, mouse)
RN  - EC 2.7.1.- (Dclk1 protein, rat)
RN  - EC 2.7.1.11 (DCLK1 protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Western
MH  - Brain/embryology/*enzymology/*growth & development
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*biosynthesis/*genetics
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Gene Library
MH  - Humans
MH  - In Situ Hybridization
MH  - Intracellular Signaling Peptides and Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*biosynthesis/genetics
MH  - Plasmids/genetics
MH  - *Protein-Serine-Threonine Kinases
MH  - RNA Probes
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transfection
EDAT- 1999/10/26 00:00
MHDA- 1999/10/26 00:01
CRDT- 1999/10/26 00:00
PHST- 1999/10/26 00:00 [pubmed]
PHST- 1999/10/26 00:01 [medline]
PHST- 1999/10/26 00:00 [entrez]
AID - 10.1002/(SICI)1097-4547(19991115)58:4<567::AID-JNR9>3.0.CO;2-T [pii]
PST - ppublish
SO  - J Neurosci Res. 1999 Nov 15;58(4):567-75.