PMID- 10531062
OWN - NLM
STAT- MEDLINE
DCOM- 19991105
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 286
IP  - 5440
DP  - 1999 Oct 22
TI  - Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.
PG  - 771-4
AB  - Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling to
      regulate cell growth and differentiation. The SnoN oncoprotein was found to
      interact with Smad2 and Smad4 and to repress their abilities to activate
      transcription through recruitment of the transcriptional corepressor N-CoR.
      Immediately after TGF-beta stimulation, SnoN is rapidly degraded by the nuclear
      accumulation of Smad3, allowing the activation of TGF-beta target genes. By 2
      hours, TGF-beta induces a marked increase in SnoN expression, resulting in
      termination of Smad-mediated transactivation. Thus, SnoN maintains the repressed 
      state of TGF-beta-responsive genes in the absence of ligand and participates in
      negative feedback regulation of TGF-beta signaling.
FAU - Stroschein, S L
AU  - Stroschein SL
AD  - Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of 
      Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall,
      Mail Code 3206, Berkeley, CA 94720, USA.
FAU - Wang, W
AU  - Wang W
FAU - Zhou, S
AU  - Zhou S
FAU - Zhou, Q
AU  - Zhou Q
FAU - Luo, K
AU  - Luo K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NCOR1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Co-Repressor 1)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SKIL protein, human)
RN  - 0 (SMAD2 protein, human)
RN  - 0 (SMAD3 protein, human)
RN  - 0 (SMAD4 protein, human)
RN  - 0 (Smad2 Protein)
RN  - 0 (Smad3 Protein)
RN  - 0 (Smad4 Protein)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - 126648-96-2 (SKI protein, human)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Science. 1999 Oct 22;286(5440):665. PMID: 10577218
MH  - Cell Division
MH  - Cell Line
MH  - Cell Nucleus/metabolism
MH  - DNA/metabolism
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Feedback
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Nuclear Proteins/metabolism
MH  - Nuclear Receptor Co-Repressor 1
MH  - Promoter Regions, Genetic
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Repressor Proteins/metabolism
MH  - *Signal Transduction
MH  - Smad2 Protein
MH  - Smad3 Protein
MH  - Smad4 Protein
MH  - Trans-Activators/genetics/metabolism
MH  - Transcription Factors/genetics/*metabolism
MH  - Transcriptional Activation
MH  - Transfection
MH  - Transforming Growth Factor beta/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 1999/10/26 00:00
MHDA- 1999/10/26 00:01
CRDT- 1999/10/26 00:00
PHST- 1999/10/26 00:00 [pubmed]
PHST- 1999/10/26 00:01 [medline]
PHST- 1999/10/26 00:00 [entrez]
AID - 7926 [pii]
AID - 10.1126/science.286.5440.771 [doi]
PST - ppublish
SO  - Science. 1999 Oct 22;286(5440):771-4. doi: 10.1126/science.286.5440.771.