PMID- 10529425
OWN - NLM
STAT- MEDLINE
DCOM- 19991217
LR  - 20111117
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 126
IP  - 22
DP  - 1999 Nov
TI  - oto is a homeotic locus with a role in anteroposterior development that is
      partially redundant with Lim1.
PG  - 5085-95
AB  - Genetic control of mammalian head development involves mechanisms that are shared
      with trunk development as well as mechanisms that are independent. For example,
      mutations in the nodal gene disrupt axis formation and head development while
      mutations in the Otx2 or Lim1 genes block head development without disrupting
      development of the trunk. We show here that the oto mutation on mouse chromosome 
      1 defines a locus with a critical role in anterior development. The oto mutation 
      disrupts development of the telencephalic and optic vesicles, the pharyngeal
      endoderm and the first branchial arch. Also, oto embryos have dose-dependent,
      posterior homeotic transformations throughout the axial skeleton. To further
      dissect the role of the oto locus in head development, we crossed mice carrying
      oto and Lim1 mutations. Interactions between the two mutations indicate that the 
      role of oto in the regulation of head development is partially redundant with
      that of Lim1. The phenotype of oto embryos points to an early and critical role
      for oto in the development of forebrain subregions. Transformations of the
      vertebrae in oto embryos reveal a Lim1-independent role in the establishment of
      positional information in the trunk.
FAU - Zoltewicz, J S
AU  - Zoltewicz JS
AD  - Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA.
FAU - Plummer, N W
AU  - Plummer NW
FAU - Lin, M I
AU  - Lin MI
FAU - Peterson, A S
AU  - Peterson AS
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Homeodomain Proteins)
RN  - 0 (LHX1 protein, human)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (Lhx1 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Branchial Region/abnormalities/embryology
MH  - Embryonic and Fetal Development/*genetics
MH  - Holoprosencephaly/embryology
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - Jaw/physiology
MH  - LIM-Homeodomain Proteins
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mutation
MH  - Pharynx/abnormalities/embryology
MH  - Prosencephalon/abnormalities/embryology
MH  - Telencephalon/embryology
MH  - Transcription Factors
EDAT- 1999/10/26 00:00
MHDA- 1999/10/26 00:01
CRDT- 1999/10/26 00:00
PHST- 1999/10/26 00:00 [pubmed]
PHST- 1999/10/26 00:01 [medline]
PHST- 1999/10/26 00:00 [entrez]
PST - ppublish
SO  - Development. 1999 Nov;126(22):5085-95.