PMID- 10528161
OWN - NLM
STAT- MEDLINE
DCOM- 19991119
LR  - 20211203
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 163
IP  - 9
DP  - 1999 Nov 1
TI  - Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to 
      DAP12 but with unique signaling properties.
PG  - 4651-4
AB  - Transmembrane adapter proteins are a class of molecules that mediate signals from
      an extracellular receptor to the cytoplasm of the cell. We have cloned a novel
      transmembrane adapter protein called KAP10, a approximately 10-kDa protein that
      is encoded within 100 bp of the DAP12 locus on human chromosome 19. KAP10 is
      predominantly expressed in immune cells, including NK cells, T cells, and
      monocytes. We show that KAP10, unlike other transmembrane adapter proteins, binds
      phosphatidylinositol-3 kinase following phosphorylation of a cytoplasmic YINM
      motif, which results in activation of Akt. In addition, we identify KAP10 as
      being able to bind the adapter protein Grb2. Based on our data, we suggest that
      this molecule is involved in stimulation and costimulation in cells of both
      myeloid and lymphoid origin.
FAU - Chang, C
AU  - Chang C
AD  - Division of Immunology, Research Group in Human Reproductive Immunobiology,
      Department of Pathology, University of Cambridge, United Kingdom.
FAU - Dietrich, J
AU  - Dietrich J
FAU - Harpur, A G
AU  - Harpur AG
FAU - Lindquist, J A
AU  - Lindquist JA
FAU - Haude, A
AU  - Haude A
FAU - Loke, Y W
AU  - Loke YW
FAU - King, A
AU  - King A
FAU - Colonna, M
AU  - Colonna M
FAU - Trowsdale, J
AU  - Trowsdale J
FAU - Wilson, M J
AU  - Wilson MJ
LA  - eng
SI  - GENBANK/AF172929
SI  - GENBANK/AF172930
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CD4 Antigens)
RN  - 0 (HCST protein, human)
RN  - 0 (Hcst protein, mouse)
RN  - 0 (Immune Sera)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TYROBP protein, human)
RN  - EC 2.7.11.1 (AKT1 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - CD4 Antigens/immunology
MH  - Cell Line
MH  - Cell Lineage/genetics/immunology
MH  - Enzyme Activation
MH  - Genetic Linkage/immunology
MH  - Hematopoietic Stem Cells/metabolism
MH  - Humans
MH  - Immune Sera/metabolism
MH  - Jurkat Cells
MH  - Lymphoid Tissue/cytology/metabolism
MH  - Membrane Proteins/biosynthesis/*genetics/immunology/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Protein Binding/immunology
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-akt
MH  - Receptors, Immunologic/*genetics/metabolism
MH  - Signal Transduction/genetics/*immunology
MH  - U937 Cells
EDAT- 1999/10/21 00:00
MHDA- 1999/10/21 00:01
CRDT- 1999/10/21 00:00
PHST- 1999/10/21 00:00 [pubmed]
PHST- 1999/10/21 00:01 [medline]
PHST- 1999/10/21 00:00 [entrez]
AID - ji_v163n9p4651 [pii]
PST - ppublish
SO  - J Immunol. 1999 Nov 1;163(9):4651-4.