PMID- 10527845
OWN - NLM
STAT- MEDLINE
DCOM- 19991112
LR  - 20191210
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 264
IP  - 1
DP  - 1999 Oct 14
TI  - A tetratricopeptide repeat-containing protein gene, tpis, whose expression is
      induced with differentiation of spermatogenic cells.
PG  - 81-5
AB  - The tetratricopeptide repeat (TPR) is a degenerate 34-amino-acid sequence which
      forms scaffolds to mediate protein-protein interactions. We have isolated a cDNA 
      named tpis from mouse embryonic skin and found that the deduced 529-amino-acid
      sequence contained 5 TPRs. In addition to skin, the transcript of tpis was
      detected in tissues with stratified squamous epithelium, e.g., tongue, esophagus,
      and forestomach. tpis was most strongly expressed in testis among adult tissues
      examined. The transcript of tpis from testis was longer, encoding 372 additional 
      amino acid residues at the 5'-side with 3 more TPRs. In situ hybridization
      revealed specific expression of tpis at a distinct differentiation stage of
      spermatogenic cells, indicating involvement of tpis in spermatogenesis.
      Chromosomal localization of the tpis gene was determined as 18.10 cM of
      chromosome 15.
CI  - Copyright 1999 Academic Press.
FAU - Takaishi, M
AU  - Takaishi M
AD  - Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama,
      Sugitani, 930-0194, Japan.
FAU - Huh, N h
AU  - Huh Nh
LA  - eng
SI  - GENBANK/AF181252
SI  - GENBANK/AF181253
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antigens)
RN  - 0 (DNA, Complementary)
RN  - 0 (Proteins)
RN  - 0 (Spag1 protein, mouse)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Antigens
MH  - Chromosome Mapping
MH  - DNA, Complementary/isolation & purification
MH  - GTP-Binding Proteins
MH  - Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Molecular Sequence Data
MH  - Protein Biosynthesis
MH  - Proteins/*genetics
MH  - Repetitive Sequences, Amino Acid/genetics
MH  - Spermatogenesis/*genetics/physiology
MH  - Testis/cytology/metabolism/*physiology
EDAT- 1999/10/21 00:00
MHDA- 1999/10/21 00:01
CRDT- 1999/10/21 00:00
PHST- 1999/10/21 00:00 [pubmed]
PHST- 1999/10/21 00:01 [medline]
PHST- 1999/10/21 00:00 [entrez]
AID - 10.1006/bbrc.1999.1477 [doi]
AID - S0006291X99914778 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Oct 14;264(1):81-5. doi: 10.1006/bbrc.1999.1477.