PMID- 10526159
OWN - NLM
STAT- MEDLINE
DCOM- 19991122
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 459
IP  - 3
DP  - 1999 Oct 15
TI  - Demonstration of glycosaminoglycans in Caenorhabditis elegans.
PG  - 327-31
AB  - A considerable amount (approximately 1.6 microg from 1 mg of dried nematode) of
      non-sulfated chondroitin, two orders of magnitude less yet an appreciable amount 
      of heparan sulfate, and no hyaluronate were found in Caenorhabditis elegans
      nematodes. The chondroitin chains were heterogeneous in size, being shorter than 
      that of whale cartilage chondroitin sulfate. The disaccharide composition
      analysis of heparan sulfate revealed diverse sulfation including glucosamine
      2-N-sulfation, glucosamine 6-O-sulfation and uronate 2-O-sulfation. These results
      imply that chondroitin and heparan sulfate are involved in fundamental biological
      processes.
FAU - Yamada, S
AU  - Yamada S
AD  - Department of Biochemistry, Kobe Pharmaceutical University, 4-19-1
      Motoyamakita-machi, Higashinada-ku, Kobe, Japan.
FAU - Van Die, I
AU  - Van Die I
FAU - Van den Eijnden, D H
AU  - Van den Eijnden DH
FAU - Yokota, A
AU  - Yokota A
FAU - Kitagawa, H
AU  - Kitagawa H
FAU - Sugahara, K
AU  - Sugahara K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Glycosaminoglycans)
RN  - 9007-27-6 (Chondroitin)
RN  - 9050-30-0 (Heparitin Sulfate)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/*chemistry
MH  - Chondroitin/isolation & purification
MH  - Glycosaminoglycans/*analysis
MH  - Heparitin Sulfate/isolation & purification
MH  - Magnetic Resonance Spectroscopy
EDAT- 1999/10/20 00:00
MHDA- 1999/10/20 00:01
CRDT- 1999/10/20 00:00
PHST- 1999/10/20 00:00 [pubmed]
PHST- 1999/10/20 00:01 [medline]
PHST- 1999/10/20 00:00 [entrez]
AID - S0014-5793(99)01286-7 [pii]
AID - 10.1016/s0014-5793(99)01286-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Oct 15;459(3):327-31. doi: 10.1016/s0014-5793(99)01286-7.