PMID- 10526152
OWN - NLM
STAT- MEDLINE
DCOM- 19991122
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 459
IP  - 3
DP  - 1999 Oct 15
TI  - Identification and molecular characterization of BP75, a novel
      bromodomain-containing protein.
PG  - 291-8
AB  - We here describe the identification and characterization of a novel
      bromodomain-containing protein, the bromodomain protein of 75 kDa (BP75).
      Initially, we identified BP75 in a two-hybrid screening for proteins that
      interact with the first PDZ (acronym for post-synaptic density protein PSD-95,
      Drosophila discs large tumor suppressor DlgA and the tight junction protein ZO-1)
      domain in protein tyrosine phosphatase-BAS-like (PTP-BL). We found that BP75 is
      expressed ubiquitously and show that both BP75 and a PTP-BL deletion mutant
      consisting of the first PDZ domain are located mainly in the nucleus, although
      cytoplasmic localization is also evident. Full-length PTP-BL, on the contrary, is
      predominantly localized in the cytoplasm, although some basal nuclear staining is
      observed. The described molecular interaction may reflect a mechanism of coupling
      submembraneous signalling events and nuclear events.
FAU - Cuppen, E
AU  - Cuppen E
AD  - Department of Cell Biology, Institute of Cellular Signalling, University of
      Nijmegen, Adelbertusplein 1, 6525 EK, Nijmegen, The Netherlands.
FAU - van Ham, M
AU  - van Ham M
FAU - Pepers, B
AU  - Pepers B
FAU - Wieringa, B
AU  - Wieringa B
FAU - Hendriks, W
AU  - Hendriks W
LA  - eng
SI  - GENBANK/AF084259
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Brd7 protein, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (DNA, Complementary)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, mouse)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (postsynaptic density proteins)
RN  - EC 2.7.4.8 (Guanylate Kinases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 13)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Ptpn13 protein, mouse)
RN  - SBV4XY874G (Bromine)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bromine/*chemistry
MH  - COS Cells
MH  - Carrier Proteins/*genetics/isolation & purification/metabolism
MH  - *Chromosomal Proteins, Non-Histone
MH  - *Conserved Sequence
MH  - DNA, Complementary/metabolism
MH  - Disks Large Homolog 4 Protein
MH  - Guanylate Kinases
MH  - Intracellular Signaling Peptides and Proteins
MH  - Membrane Proteins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/metabolism
MH  - Nuclear Proteins/*genetics/isolation & purification/metabolism
MH  - Protein Structure, Tertiary
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 13
MH  - Protein Tyrosine Phosphatases/chemistry/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Subcellular Fractions/metabolism
MH  - Two-Hybrid System Techniques
EDAT- 1999/10/20 00:00
MHDA- 1999/10/20 00:01
CRDT- 1999/10/20 00:00
PHST- 1999/10/20 00:00 [pubmed]
PHST- 1999/10/20 00:01 [medline]
PHST- 1999/10/20 00:00 [entrez]
AID - S0014-5793(99)01191-6 [pii]
AID - 10.1016/s0014-5793(99)01191-6 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Oct 15;459(3):291-8. doi: 10.1016/s0014-5793(99)01191-6.