PMID- 10524249
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 237
IP  - 1
DP  - 1999 Sep 3
TI  - The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.
PG  - 185-91
AB  - Polycomb group genes were originally identified in Drosophila as repressors
      required to maintain the silenced state of homeotic loci. About ten Polycomb
      group genes have been cloned in Drosophila, and mammalian homologs have been
      identified for most of these. Here, we isolate cDNAs encoding two isoforms of a
      human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg
      homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart
      Scmh1, and 41% identity to Scm, and contains two 1(3)mbt domains, and the SPM
      domain that are characteristic of Scm. SCMH1 is widely expressed in adult
      tissues, and maps to chromosome 1p34.
FAU - Berger, J
AU  - Berger J
AD  - Chiron Corporation, Emeryville, CA 94608-2916, USA.
FAU - Kurahashi, H
AU  - Kurahashi H
FAU - Takihara, Y
AU  - Takihara Y
FAU - Shimada, K
AU  - Shimada K
FAU - Brock, H W
AU  - Brock HW
FAU - Randazzo, F
AU  - Randazzo F
LA  - eng
SI  - GENBANK/AF149045
SI  - GENBANK/AF149046
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Pc protein, Drosophila)
RN  - 0 (Polycomb-Group Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Repressor Proteins)
RN  - 0 (SCM protein, Drosophila)
RN  - EC 2.3.2.27 (Polycomb Repressive Complex 1)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/*analysis
MH  - DNA-Binding Proteins/chemistry/*genetics
MH  - Drosophila/genetics
MH  - *Drosophila Proteins
MH  - Gene Expression Regulation
MH  - Humans
MH  - Insect Proteins/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Polycomb Repressive Complex 1
MH  - Polycomb-Group Proteins
MH  - Protein Isoforms
MH  - Repressor Proteins/chemistry/*genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/10/19 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/10/19 09:00
PHST- 1999/10/19 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/10/19 09:00 [entrez]
AID - S0378-1119(99)00285-1 [pii]
AID - 10.1016/s0378-1119(99)00285-1 [doi]
PST - ppublish
SO  - Gene. 1999 Sep 3;237(1):185-91. doi: 10.1016/s0378-1119(99)00285-1.