PMID- 10524244
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 237
IP  - 1
DP  - 1999 Sep 3
TI  - Developmentally-regulated expression of mNapor encoding an apoptosis-induced
      ELAV-type RNA binding protein.
PG  - 135-42
AB  - Proteins with RNA recognition motifs (RRMs) participate in many aspects of RNA
      metabolism, and some of them are required for the accomplishment of normal
      development. The neuroblastoma apoptosis-related RNA binding protein (NAPOR) is
      an ELAV-type RNA-binding protein with three characteristic RNP2/RNP1-type RRMs,
      which we identified as a gene induced during apoptosis of neuroblastoma cells.
      Here we isolated and characterized the cDNA for mNapor, the mouse homolog of
      NAPOR. The mNapor encodes mRNA sharing striking homology with that of NAPOR, not 
      only in its open reading frame (98.5%) but also in the 3'-untranslated region
      (80.1%), and is mapped to chromosome 2 A2-A3, a region syntenic to the human
      NAPOR locus. In situ hybridization analysis revealed that the expression pattern 
      of mNapor is spatially and temporally coincident with the occurrence of
      programmed cell death, suggesting its involvement in the development of the
      central nervous system in which apoptosis plays a crucial role.
FAU - Choi, D K
AU  - Choi DK
AD  - Human Genome Center, University of Tokyo, Japan.
FAU - Ito, T
AU  - Ito T
FAU - Tsukahara, F
AU  - Tsukahara F
FAU - Hirai, M
AU  - Hirai M
FAU - Sakaki, Y
AU  - Sakaki Y
LA  - eng
SI  - GENBANK/AF036956
SI  - GENBANK/AF090693
SI  - GENBANK/AF090695
SI  - GENBANK/AF090696
SI  - GENBANK/AF090697
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (CELF Proteins)
RN  - 0 (CELF2 protein, human)
RN  - 0 (DNA, Complementary)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis/genetics
MH  - Base Sequence
MH  - CELF Proteins
MH  - Cerebral Cortex/embryology/growth & development
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins
MH  - Organ Specificity
MH  - RNA-Binding Proteins/*genetics/*metabolism
MH  - Spinal Cord/embryology/growth & development
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
AID - S0378-1119(99)00312-1 [pii]
AID - 10.1016/s0378-1119(99)00312-1 [doi]
PST - ppublish
SO  - Gene. 1999 Sep 3;237(1):135-42. doi: 10.1016/s0378-1119(99)00312-1.