PMID- 10524241
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 237
IP  - 1
DP  - 1999 Sep 3
TI  - Characterization of the rat, mouse, and human genes of growth/differentiation
      factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1).
PG  - 105-11
AB  - We have isolated the rat, mouse and human genes of a distant member of the
      TGF-beta superfamily, growth/differentiation factor-15/macrophage inhibiting
      cytokine-1 (GDF-15/MIC-1) by screening of genomic libraries. All three genes are 
      composed of two exons, and contain one single intron that interrupts the coding
      sequences at identical positions within the prepro-domain of the corresponding
      proteins. The predicted proteins contain the structural hallmarks of members of
      the TGF-beta superfamily, including the seven conserved carboxy-terminal cysteine
      residues that form the cystine knot. The orthologous molecules show the lowest
      sequence conservation of all members of the TGF-beta superfamily. RT-PCR reveals 
      an abundant expression of GDF-15/MIC-1 mRNA in numerous embryonic and adult
      organs and tissues. Promoter analysis of the rat promoter indicates the presence 
      of multiple regulatory elements, including a TATA-like sequence as well as
      several SP1, AP-1 and AP-2 sites. Deletion analysis suggests that a 350 bp region
      upstream of the start of the open reading frame appears to be the most important 
      for regulation of transcription.
FAU - Bottner, M
AU  - Bottner M
AD  - Department of Neuroanatomy, University of Heidelberg, Germany.
      un691mb@genius.embnet.dkfz-heidelberg.de
FAU - Laaff, M
AU  - Laaff M
FAU - Schechinger, B
AU  - Schechinger B
FAU - Rappold, G
AU  - Rappold G
FAU - Unsicker, K
AU  - Unsicker K
FAU - Suter-Crazzolara, C
AU  - Suter-Crazzolara C
LA  - eng
SI  - GENBANK/AJ011967
SI  - GENBANK/AJ011968
SI  - GENBANK/AJ011969
SI  - GENBANK/AJ011970
SI  - GENBANK/AJ011971
SI  - GENBANK/AJ011972
SI  - GENBANK/AJ011973
SI  - GENBANK/AJ011974
SI  - GENBANK/AJ011975
SI  - GENBANK/AJ011976
SI  - GENBANK/AJ011977
SI  - GENBANK/AJ011978
SI  - GENBANK/AJ011979
SI  - GENBANK/AJ011980
SI  - GENBANK/AJ011981
SI  - GENBANK/AJ011982
SI  - GENBANK/AJ011983
SI  - GENBANK/AJ011984
SI  - GENBANK/AJ011985
SI  - GENBANK/AJ011986
SI  - GENBANK/AJ011987
SI  - GENBANK/AJ011988
SI  - GENBANK/AJ011989
SI  - GENBANK/AJ011990
SI  - GENBANK/AJ011991
SI  - GENBANK/AJ011992
SI  - GENBANK/AJ011993
SI  - GENBANK/AJ011994
SI  - GENBANK/AJ011995
SI  - GENBANK/AJ011996
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Cytokines)
RN  - 0 (GDF15 protein, human)
RN  - 0 (Gdf15 protein, mouse)
RN  - 0 (Gdf15 protein, rat)
RN  - 0 (Growth Differentiation Factor 15)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cytokines/*genetics/metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Growth Differentiation Factor 15
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger
MH  - Rats
MH  - Regulatory Sequences, Nucleic Acid
MH  - Sequence Homology, Amino Acid
MH  - Transforming Growth Factor beta/genetics/metabolism
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
AID - S0378-1119(99)00309-1 [pii]
AID - 10.1016/s0378-1119(99)00309-1 [doi]
PST - ppublish
SO  - Gene. 1999 Sep 3;237(1):105-11. doi: 10.1016/s0378-1119(99)00309-1.