PMID- 10524237
OWN - NLM
STAT- MEDLINE
DCOM- 19991102
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 237
IP  - 1
DP  - 1999 Sep 3
TI  - The identification of seven metalloproteinase-disintegrin (ADAM) genes from
      genomic libraries.
PG  - 61-70
AB  - Metalloproteinase-disintegrins (ADAMs) are membrane-spanning multi-domain
      proteins containing a zinc metalloproteinase domain and a disintegrin domain
      which may serve as an integrin ligand. Based on a conserved sequence within the
      disintegrin domain, GE(E/Q)CDCG, seven genes were isolated from a human genomic
      library. Two of these genes lack introns and show testis-specific expression
      (ADAM20 and ADAM21), while the other two genes contain introns (ADAM22 and
      ADAM23) and are expressed predominantly in the brain. In addition, three
      pseudogenes were isolated; one of which evolved from ADAM21. Human chromosomal
      mapping indicated that ADAM22 and ADAM23 mapped to chromosome 7q21 and 2q33,
      respectively, while the three pseudogenes 1-2, 3-3, and 1-32 mapped to chromosome
      14q24.1, 8p23, and 14q24.1, respectively. An ancestral analysis of all known
      ADAMs indicates that the zinc-binding motif in the catalytic domain arose once in
      a common ancestor and was lost by those members lacking this motif.
FAU - Poindexter, K
AU  - Poindexter K
AD  - Immunex Corporation, Seattle, WA 98101, USA.
FAU - Nelson, N
AU  - Nelson N
FAU - DuBose, R F
AU  - DuBose RF
FAU - Black, R A
AU  - Black RA
FAU - Cerretti, D P
AU  - Cerretti DP
LA  - eng
SI  - GENBANK/AF158637
SI  - GENBANK/AF158638
SI  - GENBANK/AF158639
SI  - GENBANK/AF158640
SI  - GENBANK/AF158641
SI  - GENBANK/AF158642
SI  - GENBANK/AF158643
SI  - GENBANK/AF158644
PT  - Journal Article
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Disintegrins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Oligonucleotides)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.- (ADAM20 protein, human)
RN  - EC 3.4.24.- (ADAM21 protein, human)
RN  - EC 3.4.24.- (ADAM22 protein, human)
RN  - EC 3.4.24.- (Adam23 protein, mouse)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - ADAM Proteins
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Chromosomes, Human
MH  - Conserved Sequence
MH  - Disintegrins/*genetics
MH  - Evolution, Molecular
MH  - Genomic Library
MH  - Humans
MH  - Introns
MH  - *Membrane Proteins
MH  - Metalloendopeptidases/*genetics/metabolism
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/genetics
MH  - Oligonucleotides/genetics
MH  - *Phylogeny
MH  - Pseudogenes
MH  - Sequence Homology, Amino Acid
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
AID - S0378-1119(99)00302-9 [pii]
AID - 10.1016/s0378-1119(99)00302-9 [doi]
PST - ppublish
SO  - Gene. 1999 Sep 3;237(1):61-70. doi: 10.1016/s0378-1119(99)00302-9.