PMID- 10524219
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1446
IP  - 3
DP  - 1999 Sep 3
TI  - The human gene coding for HCN2, a pacemaker channel of the heart.
PG  - 419-25
AB  - Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, underlying
      'pacemaker' currents (I(f)/Ih), are involved in pacemaker activity of cardiac
      sinoatrial node myocytes and central neurons. Several cDNAs deriving from four
      different genes were recently identified which code for channels characterized by
      six transmembrane domains and a cyclic nucleotide binding domain. We report here 
      the identification of the human HCN2 gene and show that its functional expression
      in a human kidney cell line generates a current with properties similar to the
      native pacemaker f-channel of the heart. The hHCN2 gene maps to the telomeric
      region of chromosome 19, band p13.3. This is the first identification of a
      genetic locus coding for an HCN channel.
FAU - Vaccari, T
AU  - Vaccari T
AD  - Istituto di Genetica, Bari, Italy.
FAU - Moroni, A
AU  - Moroni A
FAU - Rocchi, M
AU  - Rocchi M
FAU - Gorza, L
AU  - Gorza L
FAU - Bianchi, M E
AU  - Bianchi ME
FAU - Beltrame, M
AU  - Beltrame M
FAU - DiFrancesco, D
AU  - DiFrancesco D
LA  - eng
SI  - GENBANK/AF065164
GR  - 971/Telethon/Italy
GR  - E.0672/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (DNA, Complementary)
RN  - 0 (HCN2 protein, human)
RN  - 0 (Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels)
RN  - 0 (Ion Channels)
RN  - 0 (Muscle Proteins)
RN  - 0 (Potassium Channels)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Line
MH  - Chromosomes, Human, Pair 19
MH  - DNA, Complementary/chemistry
MH  - Heart/*physiology
MH  - Heart Rate/*genetics
MH  - Humans
MH  - Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
MH  - In Situ Hybridization, Fluorescence
MH  - Ion Channels/*genetics
MH  - Kidney/metabolism
MH  - Molecular Sequence Data
MH  - *Muscle Proteins
MH  - Potassium Channels
MH  - Sequence Alignment
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
AID - S0167-4781(99)00092-5 [pii]
AID - 10.1016/s0167-4781(99)00092-5 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Sep 3;1446(3):419-25. doi:
      10.1016/s0167-4781(99)00092-5.