PMID- 10523670
OWN - NLM
STAT- MEDLINE
DCOM- 19991124
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 11
DP  - 1999 Nov
TI  - HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional
      corepressor.
PG  - 7816-27
AB  - Histone acetylation plays an important role in regulating chromatin structure and
      thus gene expression. Here we describe the functional characterization of HDAC4, 
      a human histone deacetylase whose C-terminal part displays significant sequence
      similarity to the deacetylase domain of yeast HDA1. HDAC4 is expressed in various
      adult human tissues, and its gene is located at chromosome band 2q37. HDAC4
      possesses histone deacetylase activity intrinsic to its C-terminal domain. When
      tethered to a promoter, HDAC4 represses transcription through two independent
      repression domains, with repression domain 1 consisting of the N-terminal 208
      residues and repression domain 2 containing the deacetylase domain. Through a
      small region located at its N-terminal domain, HDAC4 interacts with the MADS-box 
      transcription factor MEF2C. Furthermore, HDAC4 and MEF2C individually upregulate 
      but together downmodulate c-jun promoter activity. These results suggest that
      HDAC4 interacts with transcription factors such as MEF2C to negatively regulate
      gene expression.
FAU - Wang, A H
AU  - Wang AH
AD  - Molecular Oncology Group, Department of Medicine, McGill University, Montreal,
      Quebec, Canada.
FAU - Bertos, N R
AU  - Bertos NR
FAU - Vezmar, M
AU  - Vezmar M
FAU - Pelletier, N
AU  - Pelletier N
FAU - Crosato, M
AU  - Crosato M
FAU - Heng, H H
AU  - Heng HH
FAU - Th'ng, J
AU  - Th'ng J
FAU - Han, J
AU  - Han J
FAU - Yang, X J
AU  - Yang XJ
LA  - eng
SI  - GENBANK/AF124924
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MADS Domain Proteins)
RN  - 0 (MEF2 Transcription Factors)
RN  - 0 (MEF2C protein, human)
RN  - 0 (Myogenic Regulatory Factors)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 3.5.1.98 (HDAC4 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 2
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/metabolism
MH  - Gene Expression Regulation
MH  - Histone Deacetylases/genetics/*metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - MADS Domain Proteins
MH  - MEF2 Transcription Factors
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Myogenic Regulatory Factors
MH  - Promoter Regions, Genetic
MH  - Protein Binding
MH  - Proto-Oncogene Proteins c-jun/genetics
MH  - Repressor Proteins/genetics/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Transcription Factors/metabolism
MH  - *Transcription, Genetic
PMC - PMC84849
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
AID - 10.1128/mcb.19.11.7816 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 Nov;19(11):7816-27. doi: 10.1128/mcb.19.11.7816.