PMID- 10523497
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20061115
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 112 ( Pt 21)
DP  - 1999 Nov
TI  - Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell
      interactions and triggering signals by protein-ectodomain shedding.
PG  - 3603-17
AB  - Metalloprotease-disintegrins (ADAMs) have captured our attention as key players
      in fertilization and in the processing of the ectodomains of proteins such as
      tumor necrosis factor (&agr;) (TNF(&agr;)), and because of their roles in
      Notch-mediated signaling, neurogenesis and muscle fusion. ADAMs are integral
      membrane glycoproteins that contain a disintegrin domain, which is related to
      snake-venom integrin ligands, and a metalloprotease domain (which can contain or 
      lack a catalytic site). Here, we review and critically discuss current topics in 
      the ADAMs field, including the central role of fertilin in fertilization, the
      role of the TNF(&agr;) convertase in protein ectodomain processing, the role of
      Kuzbanian in Notch signaling, and links between ADAMs and processing of the
      amyloid-precursor protein.
FAU - Schlondorff, J
AU  - Schlondorff J
AD  - Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer
      Center, Box 368, Tri-Institutional (Cornell/ Rockefeller
      University/Sloan-Kettering Institute) MD/PhD Program, New York, NY 10021, USA.
FAU - Blobel, C P
AU  - Blobel CP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Animals
MH  - Cell Communication/*physiology
MH  - Fertilization/physiology
MH  - Metalloendopeptidases/chemistry/*physiology
MH  - Protein Structure, Tertiary
MH  - Signal Transduction/*physiology
RF  - 157
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
PST - ppublish
SO  - J Cell Sci. 1999 Nov;112 ( Pt 21):3603-17.