PMID- 10523496
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20131121
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 112 ( Pt 21)
DP  - 1999 Nov
TI  - Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine 
      kinases.
PG  - 3591-601
AB  - During the past five years, a growing number of serine-threonine kinases highly
      homologous to the Saccharomyces cerevisiae Ipl1p kinase have been isolated in
      various organisms. A Drosophila melanogaster homologue, aurora, was the first to 
      be isolated from a multicellular organism. Since then, several related kinases
      have been found in mammalian cells. They localise to the mitotic apparatus: in
      the centrosome, at the poles of the bipolar spindle or in the midbody. The
      kinases are necessary for completion of mitotic events such as centrosome
      separation, bipolar spindle assembly and chromosome segregation. Extensive
      research is now focusing on these proteins because the three human homologues are
      overexpressed in various primary cancers. Furthermore, overexpression of one of
      these kinases transforms cells. Because of the myriad of kinases identified, we
      suggest a generic name: Aurora/Ipl1p-related kinase (AIRK). We denote AIRKs with 
      a species prefix and a number, e.g. HsAIRK1.
FAU - Giet, R
AU  - Giet R
AD  - CNRS UPR41| Universite de Rennes I, Groupe Cycle Cellulaire, Faculte de Medecine,
      CS 34317, France.
FAU - Prigent, C
AU  - Prigent C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Oncogene Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Aurora Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Aurora Kinases
MH  - Humans
MH  - Mitosis/*genetics
MH  - Multigene Family/genetics
MH  - Oncogene Proteins/chemistry/classification/*genetics
MH  - Protein Kinases/chemistry/*classification/*genetics
MH  - Protein-Serine-Threonine Kinases/chemistry/*classification/*genetics
RF  - 100
EDAT- 1999/10/19 00:00
MHDA- 1999/10/19 00:01
CRDT- 1999/10/19 00:00
PHST- 1999/10/19 00:00 [pubmed]
PHST- 1999/10/19 00:01 [medline]
PHST- 1999/10/19 00:00 [entrez]
PST - ppublish
SO  - J Cell Sci. 1999 Nov;112 ( Pt 21):3591-601.