PMID- 10523298
OWN - NLM
STAT- MEDLINE
DCOM- 19991206
LR  - 20081120
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 20
DP  - 1999 Oct 15
TI  - Oncogenic potential of EAG K(+) channels.
PG  - 5540-7
AB  - We have investigated the possible implication of the cell cycle-regulated K(+)
      channel ether a go-go (EAG) in cell proliferation and transformation. We show
      that transfection of EAG into mammalian cells confers a transformed phenotype. In
      addition, human EAG mRNA is detected in several somatic cancer cell lines,
      despite being preferentially expressed in brain among normal tissues. Inhibition 
      of EAG expression in several of these cancer cell lines causes a significant
      reduction of cell proliferation. Moreover, the expression of EAG favours tumour
      progression when transfected cells are injected into immune-depressed mice. These
      data provide evidence for the oncogenic potential of EAG.
FAU - Pardo, L A
AU  - Pardo LA
AD  - Max-Planck-Institut fur experimentelle Medizin, Hermann-Rein-Strasse 3, D-37075
      Gottingen, Germany. pardo@mail.mpiem.gwdg.de
FAU - del Camino, D
AU  - del Camino D
FAU - Sanchez, A
AU  - Sanchez A
FAU - Alves, F
AU  - Alves F
FAU - Bruggemann, A
AU  - Bruggemann A
FAU - Beckh, S
AU  - Beckh S
FAU - Stuhmer, W
AU  - Stuhmer W
LA  - eng
SI  - GENBANK/AF078741
SI  - GENBANK/AF078742
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (DNA Primers)
RN  - 0 (Ether-A-Go-Go Potassium Channels)
RN  - 0 (KCNH1 protein, human)
RN  - 0 (Kcnh1 protein, mouse)
RN  - 0 (Oligodeoxyribonucleotides, Antisense)
RN  - 0 (Potassium Channels)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Division/drug effects/genetics/physiology
MH  - *Cell Transformation, Neoplastic/genetics/metabolism
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - Ether-A-Go-Go Potassium Channels
MH  - Gene Expression
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Mice, SCID
MH  - Molecular Sequence Data
MH  - Neoplasms, Experimental/genetics/metabolism/pathology
MH  - Oligodeoxyribonucleotides, Antisense/genetics/pharmacology
MH  - Phenotype
MH  - Potassium Channels/genetics/*physiology
MH  - RNA, Messenger/genetics/metabolism
MH  - Tumor Cells, Cultured
PMC - PMC1171622
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.1093/emboj/18.20.5540 [doi]
PST - ppublish
SO  - EMBO J. 1999 Oct 15;18(20):5540-7. doi: 10.1093/emboj/18.20.5540.