PMID- 10521921
OWN - NLM
STAT- MEDLINE
DCOM- 19991119
LR  - 20081121
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 152
IP  - 5
DP  - 1999 Nov
TI  - A novel human stress response-related gene with a potential role in induced
      radioresistance.
PG  - 451-61
AB  - We have isolated a novel gene, DIR1, from L132 cells that is transiently
      repressed after exposure to low radiation doses and has a potential role in
      induced radioresistance. Molecular and cellular characterization of this gene
      reveals that it is unique but has similarities to a family of heat-shock-related 
      proteins known as immunophilins. These have been implicated in various cellular
      functions including general stress responses and control of the cell cycle.
      Antisense strategies have demonstrated that the DIR1 gene also appears to have
      some involvement in the control of the cell cycle. Furthermore, there appears be 
      a potential role for this gene product in the phenomenon of induced
      radioresistance through a mechanism that increases the rate of DNA repair in
      cells exposed to X rays and subsequently increases the cells' resistance to
      radiation. This is the first description of an immunophilin-like gene that has a 
      possible role in adaptive/inducible responses to X rays in mammalian cells.
FAU - Robson, T
AU  - Robson T
AD  - Radiation Science Group, School of Biomedical Sciences, University of Ulster,
      Newtownabbey, Co. Antrim, BT37 OQB, Northern Ireland, United Kingdom.
FAU - Joiner, M C
AU  - Joiner MC
FAU - Wilson, G D
AU  - Wilson GD
FAU - McCullough, W
AU  - McCullough W
FAU - Price, M E
AU  - Price ME
FAU - Logan, I
AU  - Logan I
FAU - Jones, H
AU  - Jones H
FAU - McKeown, S R
AU  - McKeown SR
FAU - Hirst, D G
AU  - Hirst DG
LA  - eng
SI  - GENBANK/AF139374
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 0 (DNA, Complementary)
RN  - 0 (FKBPL protein, human)
RN  - 0 (Oligonucleotides, Antisense)
RN  - EC 5.2.1.8 (Immunophilins)
SB  - IM
SB  - S
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Cycle/genetics
MH  - Cell Survival/genetics
MH  - DNA Repair/genetics
MH  - DNA, Complementary
MH  - Humans
MH  - Immunophilins/*genetics
MH  - Molecular Sequence Data
MH  - Oligonucleotides, Antisense/genetics
MH  - Radiation Tolerance/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Stress, Physiological/*genetics
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
PST - ppublish
SO  - Radiat Res. 1999 Nov;152(5):451-61.