PMID- 10521599
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 72
IP  - 1
DP  - 1999 Sep 8
TI  - Cortistatin and somatostatin mRNAs are differentially regulated in response to
      kainate.
PG  - 55-64
AB  - Cortistatin (CST) is a presumptive neuropeptide that shares 11 of its 14 amino
      acids with somatostatin (SST). CST and SST are expressed in partially overlapping
      but distinct populations of cortical interneurons. In the hippocampal formation, 
      most CST-positive cells are also positive for SST. In contrast to SST,
      administration of CST into the rat brain ventricles reduces locomotor activity
      and specifically enhances slow wave sleep. Intracerebroventricular injection of
      CST or SST has been shown to protect against the neurotoxic effects of kainic
      acid. Here, we show that CST and SST mRNAs respond differently to kainate-induced
      seizures. Furthermore, comparison of the upstream sequences from the CST and SST 
      precursor genes reveal that they contain binding motifs for different
      transcriptional regulatory factors. Our data demonstrate that CST and SST, which 
      are often co-expressed in the same neurons, are regulated by different stimuli.
FAU - Calbet, M
AU  - Calbet M
AD  - Department of Molecular Biology, MB-10, The Scripps Research Institute, 10550
      North Torrey Pines Rd., La Jolla, CA, USA.
FAU - Guadano-Ferraz, A
AU  - Guadano-Ferraz A
FAU - Spier, A D
AU  - Spier AD
FAU - Maj, M
AU  - Maj M
FAU - Sutcliffe, J G
AU  - Sutcliffe JG
FAU - Przewlocki, R
AU  - Przewlocki R
FAU - de Lecea, L
AU  - de Lecea L
LA  - eng
SI  - GENBANK/AF050156
GR  - R01MH58543/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (cortistatin)
RN  - 0 (preprocortistatin)
RN  - 51110-01-1 (Somatostatin)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Cloning, Molecular
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Gene Expression Regulation/*drug effects
MH  - *Genes
MH  - Hippocampus/drug effects/metabolism
MH  - In Situ Hybridization
MH  - Interneurons/metabolism
MH  - Kainic Acid/*pharmacology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/biosynthesis/*genetics
MH  - Neuropeptides/biosynthesis/*genetics
MH  - Promoter Regions, Genetic
MH  - Protein Precursors/*genetics
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regulatory Sequences, Nucleic Acid
MH  - Seizures/chemically induced/genetics/metabolism
MH  - Somatostatin/biosynthesis/*genetics
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0169328X9900220X [pii]
AID - 10.1016/s0169-328x(99)00220-x [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Sep 8;72(1):55-64. doi:
      10.1016/s0169-328x(99)00220-x.