PMID- 10521578
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 71
IP  - 2
DP  - 1999 Aug 25
TI  - Circadian regulation of cryptochrome genes in the mouse.
PG  - 238-43
AB  - Cryptochromes are non-opsin photoactive pigments which have been recently
      implicated in circadian photoentrainment. In humans and mice, two cryptochromes, 
      called CRY1 and CRY2, have been identified. Previously, it was shown that the
      expression of mCry1 oscillates with circadian periodicity in the suprachiasmatic 
      nucleus (SCN) of the mouse. Herein, we have investigated the expression patterns 
      of both mCry1 and mCry2 in various tissues and the effect of Cry2 knockout on
      Cry1 expression. First, the expression of Cry1 in the SCN, in contrast to mPer1
      and other immediate early genes, is not inducible by acute light pulses. Second, 
      we found that Cry1 transcription follows a circadian pattern in the liver and
      skeletal muscle. Third, mutation in Cry2 causes a phase delay in Cry1 and mPer1
      expression both in the SCN and internal organs relative to wild-type animals.
      Finally, no obvious periodicity in mCry2 expression was seen in all tissues
      tested.
FAU - Miyamoto, Y
AU  - Miyamoto Y
AD  - Department of Biochemistry and Biophysics, Mary Ellen Jones Bldg., CB# 7260,
      University of North Carolina School of Medicine, Chapel Hill, NC 27599-7260, USA.
FAU - Sancar, A
AU  - Sancar A
LA  - eng
SI  - GENBANK/AB000777
SI  - GENBANK/AB002108
SI  - GENBANK/AB003433
GR  - GM31082/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (CRY1 protein, human)
RN  - 0 (CRY2 protein, human)
RN  - 0 (Cry1 protein, mouse)
RN  - 0 (Cry2 protein, mouse)
RN  - 0 (Cryptochromes)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Flavoproteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (cry protein, Drosophila)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Animals
MH  - Biological Clocks/*genetics
MH  - Cells, Cultured
MH  - *Circadian Rhythm/*physiology
MH  - Cryptochromes
MH  - *Drosophila Proteins
MH  - *Eye Proteins
MH  - Flavoproteins/*genetics
MH  - *Gene Expression Regulation
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/metabolism
MH  - *Photoreceptor Cells, Invertebrate
MH  - Receptors, G-Protein-Coupled
MH  - Ribonucleases/metabolism
MH  - Suprachiasmatic Nucleus/metabolism
MH  - Testis/metabolism
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0169328X99001928 [pii]
AID - 10.1016/s0169-328x(99)00192-8 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Aug 25;71(2):238-43. doi:
      10.1016/s0169-328x(99)00192-8.