PMID- 10521576
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 71
IP  - 2
DP  - 1999 Aug 25
TI  - Protease M/neurosin mRNA is expressed in mature oligodendrocytes.
PG  - 217-24
AB  - No proteases have been identified to be oligodendrocyte-specific though there are
      phenomena in which proteases may be committed. We have cloned a cDNA for mouse
      homologue of protease M/neurosin, serine protease, and localized its mRNA in the 
      mouse brain. The cDNA and the deduced amino acid sequences were 66% identical to 
      those of human protease M/neurosin. In situ hybridization histochemistry revealed
      that the mRNA was localized in the mature oligodendrocytes which expressed
      proteolipid protein mRNA. Developmentally, protease M/neurosin mRNA was expressed
      by oligodendrocytes 2 to 7 days after the maturation. Thus, protease M/neurosin
      may be important to the processes occurring after the maturation of
      oligodendrocytes such as myelination or turnover of the proteins in the myelin.
FAU - Yamanaka, H
AU  - Yamanaka H
AD  - Division of Structural Cell Biology, Nara Institute of Science and Technology,
      8916-5 Takayama, Ikoma, Nara, Japan.
FAU - He, X
AU  - He X
FAU - Matsumoto, K
AU  - Matsumoto K
FAU - Shiosaka, S
AU  - Shiosaka S
FAU - Yoshida, S
AU  - Yoshida S
LA  - eng
SI  - GENBANK/AA102333
SI  - GENBANK/AA562966
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.21.- (KLK6 protein, human)
RN  - EC 3.4.21.- (Kallikreins)
RN  - EC 3.4.21.- (Prss18 protein, mouse)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain Chemistry
MH  - Humans
MH  - *Kallikreins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Oligodendroglia/*metabolism
MH  - RNA, Messenger/*biosynthesis
MH  - Serine Endopeptidases/*genetics
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0169328X99001874 [pii]
AID - 10.1016/s0169-328x(99)00187-4 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1999 Aug 25;71(2):217-24. doi:
      10.1016/s0169-328x(99)00187-4.