PMID- 10521481
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 43
DP  - 1999 Oct 22
TI  - Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38
      mitogen-activated protein kinase-dependent TNF-alpha gene expression.
PG  - 30882-6
AB  - Engagement of the tumor necrosis factor-alpha (TNF-alpha) receptors by the
      TNF-alpha ligand results in the rapid induction of TNF-alpha gene expression. The
      study presented here shows that autoregulation of TNF-alpha gene transcription by
      selective signaling through tumor necrosis factor receptor 1 (TNFR1) requires p38
      mitogen-activated protein (MAP) kinase activity and the binding of the
      transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element (CRE) 
      promoter element. Consistent with these findings, TNFR1 engagement results in
      increased p38 MAP kinase activity and p38-dependent phosphorylation of ATF-2.
      Furthermore, overexpression of MADD (MAP kinase-activating death domain protein),
      an adapter protein that binds to the death domain of TNFR1 and activates MAP
      kinase cascades, results in CRE-dependent induction of TNF-alpha gene expression.
      Thus, the TNF-alpha CRE site is the target of TNFR1 stimulation and mediates the 
      autoregulation of TNF-alpha gene transcription.
FAU - Brinkman, B M
AU  - Brinkman BM
AD  - Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115,
      USA.
FAU - Telliez, J B
AU  - Telliez JB
FAU - Schievella, A R
AU  - Schievella AR
FAU - Lin, L L
AU  - Lin LL
FAU - Goldfeld, A E
AU  - Goldfeld AE
LA  - eng
GR  - CA58735/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (ATF2 protein, human)
RN  - 0 (Activating Transcription Factor 2)
RN  - 0 (Antigens, CD)
RN  - 0 (Atf2 protein, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Death Domain Receptor Signaling Adaptor Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (MADD protein, human)
RN  - 0 (Madd protein, mouse)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Activating Transcription Factor 2
MH  - Animals
MH  - Antigens, CD/*physiology
MH  - Base Sequence
MH  - Binding Sites
MH  - Carrier Proteins/genetics/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Death Domain Receptor Signaling Adaptor Proteins
MH  - *Gene Expression Regulation
MH  - Genes, Reporter
MH  - *Guanine Nucleotide Exchange Factors
MH  - Humans
MH  - L Cells
MH  - Leucine Zippers
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Promoter Regions, Genetic
MH  - Receptors, Tumor Necrosis Factor/*physiology
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Recombinant Fusion Proteins/biosynthesis
MH  - Signal Transduction
MH  - Transcription Factors/*metabolism
MH  - Transfection
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - p38 Mitogen-Activated Protein Kinases
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.1074/jbc.274.43.30882 [doi]
AID - S0021-9258(19)51761-6 [pii]
PST - ppublish
SO  - J Biol Chem. 1999 Oct 22;274(43):30882-6. doi: 10.1074/jbc.274.43.30882.