PMID- 10521347
OWN - NLM
STAT- MEDLINE
DCOM- 19991108
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 286
IP  - 5439
DP  - 1999 Oct 15
TI  - Beta-defensins: linking innate and adaptive immunity through dendritic and T cell
      CCR6.
PG  - 525-8
AB  - Defensins contribute to host defense by disrupting the cytoplasmic membrane of
      microorganisms. This report shows that human beta-defensins are also chemotactic 
      for immature dendritic cells and memory T cells. Human beta-defensin was
      selectively chemotactic for cells stably transfected to express human CCR6, a
      chemokine receptor preferentially expressed by immature dendritic cells and
      memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis
      toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the
      chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced 
      by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by
      recruiting dendritic and T cells to the site of microbial invasion through
      interaction with CCR6.
FAU - Yang, D
AU  - Yang D
AD  - Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural 
      Research Support Program, SAIC Frederick, National Cancer Institute-Frederick
      Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
FAU - Chertov, O
AU  - Chertov O
FAU - Bykovskaia, S N
AU  - Bykovskaia SN
FAU - Chen, Q
AU  - Chen Q
FAU - Buffo, M J
AU  - Buffo MJ
FAU - Shogan, J
AU  - Shogan J
FAU - Anderson, M
AU  - Anderson M
FAU - Schroder, J M
AU  - Schroder JM
FAU - Wang, J M
AU  - Wang JM
FAU - Howard, O M
AU  - Howard OM
FAU - Oppenheim, J J
AU  - Oppenheim JJ
LA  - eng
GR  - N01-CO-56000/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antibodies)
RN  - 0 (CCL20 protein, human)
RN  - 0 (CCR6 protein, human)
RN  - 0 (Chemokine CCL20)
RN  - 0 (Chemokines, CC)
RN  - 0 (DEFB4A protein, human)
RN  - 0 (Defensins)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, CCR6)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Virulence Factors, Bordetella)
RN  - 0 (beta-Defensins)
RN  - EC 2.4.2.31 (Pertussis Toxin)
SB  - IM
CIN - Science. 1999 Oct 15;286(5439):420-1. PMID: 10577203
MH  - Antibodies/immunology
MH  - Binding, Competitive
MH  - Cell Line
MH  - Chemokine CCL20
MH  - Chemokines, CC/metabolism/pharmacology
MH  - Chemotaxis
MH  - Chemotaxis, Leukocyte
MH  - Defensins
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immunity, Active
MH  - *Immunity, Innate
MH  - Immunologic Memory
MH  - *Macrophage Inflammatory Proteins
MH  - Pertussis Toxin
MH  - Proteins/pharmacology/*physiology
MH  - Receptors, CCR6
MH  - Receptors, Chemokine/genetics/*metabolism
MH  - Recombinant Proteins/pharmacology
MH  - T-Lymphocyte Subsets/*immunology
MH  - Transfection
MH  - Virulence Factors, Bordetella/pharmacology
MH  - *beta-Defensins
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 7901 [pii]
AID - 10.1126/science.286.5439.525 [doi]
PST - ppublish
SO  - Science. 1999 Oct 15;286(5439):525-8. doi: 10.1126/science.286.5439.525.