PMID- 10520995
OWN - NLM
STAT- MEDLINE
DCOM- 19991025
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 99
IP  - 1
DP  - 1999 Oct 1
TI  - Plexins are a large family of receptors for transmembrane, secreted, and
      GPI-anchored semaphorins in vertebrates.
PG  - 71-80
AB  - In Drosophila, plexin A is a functional receptor for semaphorin-1a. Here we show 
      that the human plexin gene family comprises at least nine members in four
      subfamilies. Plexin-B1 is a receptor for the transmembrane semaphorin Sema4D
      (CD100), and plexin-C1 is a receptor for the GPI-anchored semaphorin Sema7A
      (Sema-K1). Secreted (class 3) semaphorins do not bind directly to plexins, but
      rather plexins associate with neuropilins, coreceptors for these semaphorins.
      Plexins are widely expressed: in neurons, the expression of a truncated plexin-A1
      protein blocks axon repulsion by Sema3A. The cytoplasmic domain of plexins
      associates with a tyrosine kinase activity. Plexins may also act as ligands
      mediating repulsion in epithelial cells in vitro. We conclude that plexins are
      receptors for multiple (and perhaps all) classes of semaphorins, either alone or 
      in combination with neuropilins, and trigger a novel signal transduction pathway 
      controlling cell repulsion.
FAU - Tamagnone, L
AU  - Tamagnone L
AD  - Institute for Cancer Research and Treatment, University of Torino, Candiolo,
      Italy. Itamagnone@ircc.unito.it
FAU - Artigiani, S
AU  - Artigiani S
FAU - Chen, H
AU  - Chen H
FAU - He, Z
AU  - He Z
FAU - Ming, G I
AU  - Ming GI
FAU - Song, H
AU  - Song H
FAU - Chedotal, A
AU  - Chedotal A
FAU - Winberg, M L
AU  - Winberg ML
FAU - Goodman, C S
AU  - Goodman CS
FAU - Poo, M
AU  - Poo M
FAU - Tessier-Lavigne, M
AU  - Tessier-Lavigne M
FAU - Comoglio, P M
AU  - Comoglio PM
LA  - eng
SI  - GENBANK/AJ011414
SI  - GENBANK/AJ011415
SI  - GENBANK/X87831
SI  - GENBANK/X87832
SI  - GENBANK/X87904
GR  - NS 22764/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Glycosylphosphatidylinositols)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PLXNA1 protein, human)
RN  - 0 (PLXNB1 protein, human)
RN  - 0 (Plxna1 protein, mouse)
RN  - 0 (Plxna2 protein, mouse)
RN  - 0 (Plxna3 protein, mouse)
RN  - 0 (Plxna4 protein, mouse)
RN  - 0 (Plxnb1 protein, mouse)
RN  - 0 (Receptors, Cell Surface)
RN  - 144713-63-3 (Neuropilin-1)
RN  - 42HK56048U (Tyrosine)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
EIN - Cell 2001 Jan 26;104(2):following 320
MH  - 3T3 Cells
MH  - Animals
MH  - COS Cells
MH  - Cell Communication/physiology
MH  - Cells, Cultured
MH  - Cytoplasm/metabolism
MH  - Gene Expression/physiology
MH  - Glycosylphosphatidylinositols/*metabolism
MH  - Humans
MH  - Kidney/cytology
MH  - Mesoderm/cytology
MH  - Mice
MH  - Microscopy, Video
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Nerve Tissue Proteins/chemistry/genetics/*metabolism
MH  - Neurons/chemistry/cytology/metabolism
MH  - Neuropilin-1
MH  - Phosphorylation
MH  - Protein Structure, Tertiary
MH  - Proto-Oncogene Proteins c-met/metabolism
MH  - Receptors, Cell Surface/chemistry/genetics/*metabolism
MH  - Signal Transduction/physiology
MH  - Transfection
MH  - Tyrosine/metabolism
MH  - Vertebrates
MH  - Xenopus
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - S0092-8674(00)80063-X [pii]
AID - 10.1016/s0092-8674(00)80063-x [doi]
PST - ppublish
SO  - Cell. 1999 Oct 1;99(1):71-80. doi: 10.1016/s0092-8674(00)80063-x.