PMID- 10520743
OWN - NLM
STAT- MEDLINE
DCOM- 19991105
LR  - 20191024
IS  - 1042-5179 (Print)
IS  - 1026-7913 (Linking)
VI  - 9
IP  - 3
DP  - 1998
TI  - Molecular cloning and characterization of a mouse gene with homology to the
      Duffy-antigen receptor for chemokines.
PG  - 129-43
AB  - The Duffy antigen receptor for chemokines (DARC) is a receptor for both CXC and
      CC chemokines. We have cloned a mouse gene with a predicted amino acid sequence
      homology of approximately 63% to human DARC and localized this gene to mouse
      chromosome 1 between the Xmv41 and D1Mit166 loci. We further demonstrated that,
      like the human gene, the mouse gene exhibits a single intron of 462 bp which
      interrupts the open reading frame between the codons for the seventh and eighth
      amino acid residues. Northern blot analyses revealed that putative mDARC mRNA is 
      highly expressed in adult mouse spleen and skeletal muscle and in whole embryos
      between embryonic days 8.5 to 12. Northern blot analysis of hemangiosarcomas
      which develop spontaneously in the spleen of the Eker rat reveal expression of
      mRNAs which hybridize with both DARC and CXCR2 probes, suggesting a potential
      role of these receptors in the angiogenesis associated with tumor formation.
FAU - Tang, T
AU  - Tang T
AD  - Department of Cell Biology, Vanderbilt University, School of Medicine, Nashville,
      TN 37232, USA.
FAU - Owen, J D
AU  - Owen JD
FAU - Du, J
AU  - Du J
FAU - Walker, C L
AU  - Walker CL
FAU - Richmond, A
AU  - Richmond A
LA  - eng
GR  - CA34590/CA/NCI NIH HHS/United States
GR  - CA63613/CA/NCI NIH HHS/United States
GR  - P30CA68485/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - DNA Seq
JT  - DNA sequence : the journal of DNA sequencing and mapping
JID - 9107800
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Duffy Blood-Group System/*genetics
MH  - Gene Expression
MH  - Hemangiosarcoma/genetics
MH  - Humans
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Receptors, Chemokine/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.3109/10425179809072188 [doi]
PST - ppublish
SO  - DNA Seq. 1998;9(3):129-43. doi: 10.3109/10425179809072188.