PMID- 10520737
OWN - NLM
STAT- MEDLINE
DCOM- 19991209
LR  - 20191024
IS  - 1042-5179 (Print)
IS  - 1026-7913 (Linking)
VI  - 9
IP  - 2
DP  - 1998
TI  - Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.
PG  - 89-100
AB  - Through the sequencing of a 42kb cosmid clone we describe a new gene, designated 
      PEREC1, located approximately 1.5kb centromeric of the human apolipoprotein (APO)
      E-C2 cluster. The combination of dotplot analysis, predicted coding potential and
      interrogation of the Expressed Sequence Tag (EST) database determined the genomic
      organisation of PEREC1. Sequence alignment with multiple overlapping ESTs
      confirmed the predicted splice sites. The predicted cDNA and amino acid sequences
      of PEREC1 have extensive similarity to the Caenorhabditis elegans protein,
      C18E9.6. Conserved structural and functional motifs have been defined by
      combining nucleotide and amino acid analyses to identify third base degeneracy
      and therefore selection at the protein level. The Poliovirus Receptor Related
      Protein2 gene (PRR2), previously mapped to chromosome 19q13.2 by Fluorescent
      In-Situ Hybridisation, has also been located approximately 17kb centromeric of
      APO E.
FAU - Freitas, E M
AU  - Freitas EM
AD  - Centre for Molecular Immunology and Instrumentation, University of Westem
      Australia, Nedlands.
FAU - Zhang, W J
AU  - Zhang WJ
FAU - Lalonde, J P
AU  - Lalonde JP
FAU - Tay, G K
AU  - Tay GK
FAU - Gaudieri, S
AU  - Gaudieri S
FAU - Ashworth, L K
AU  - Ashworth LK
FAU - Van Bockxmeer, F M
AU  - Van Bockxmeer FM
FAU - Dawkins, R L
AU  - Dawkins RL
LA  - eng
SI  - GENBANK/AB012576
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - DNA Seq
JT  - DNA sequence : the journal of DNA sequencing and mapping
JID - 9107800
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Helminth Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nectins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Member 14)
RN  - 0 (Receptors, Virus)
RN  - 0 (TNFRSF14 protein, human)
RN  - 0 (TOMM40 protein, human)
SB  - IM
MH  - Alzheimer Disease/genetics
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apolipoproteins E/*chemistry/*genetics
MH  - Base Sequence
MH  - Caenorhabditis elegans/genetics
MH  - Cell Adhesion Molecules
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 19/genetics
MH  - Coronary Disease/genetics
MH  - Cosmids/genetics
MH  - Databases, Factual
MH  - Expressed Sequence Tags
MH  - Helminth Proteins/chemistry/genetics
MH  - Humans
MH  - Membrane Glycoproteins/chemistry/genetics
MH  - *Membrane Transport Proteins
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Nectins
MH  - Proteins/chemistry/*genetics/metabolism
MH  - *Receptors, Tumor Necrosis Factor
MH  - Receptors, Tumor Necrosis Factor, Member 14
MH  - *Receptors, Virus
MH  - Sequence Analysis, DNA
MH  - Sequence Analysis, Protein
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
AID - 10.3109/10425179809086433 [doi]
PST - ppublish
SO  - DNA Seq. 1998;9(2):89-100. doi: 10.3109/10425179809086433.