PMID- 10519551
OWN - NLM
STAT- MEDLINE
DCOM- 19991022
LR  - 20091119
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 401
IP  - 6752
DP  - 1999 Sep 30
TI  - Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
PG  - 480-5
AB  - Members of the transforming growth factor-beta (TGF-beta) superfamily, including 
      TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for 
      regulating growth and differentiation. These growth factors transduce their
      signals through pairs of transmembrane type I and type II receptor kinases. Here,
      we have cloned a transmembrane protein, BAMBI, which is related to
      TGF-beta-family type I receptors but lacks an intracellular kinase domain. We
      show that BAMBI is co-expressed with the ventralizing morphogen BMP4 (refs 5, 6) 
      during Xenopus embryogenesis and that it requires BMP signalling for its
      expression. The protein stably associates with TGF-beta-family receptors and
      inhibits BMP and activin as well as TGF-beta signalling. Finally, we provide
      evidence that BAMBI's inhibitory effects are mediated by its intracellular
      domain, which resembles the homodimerization interface of a type I receptor and
      prevents the formation of receptor complexes. The results indicate that BAMBI
      negatively regulates TGF-beta-family signalling by a regulatory mechanism
      involving the interaction of signalling receptors with a pseudoreceptor.
FAU - Onichtchouk, D
AU  - Onichtchouk D
AD  - Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg,
      Germany.
FAU - Chen, Y G
AU  - Chen YG
FAU - Dosch, R
AU  - Dosch R
FAU - Gawantka, V
AU  - Gawantka V
FAU - Delius, H
AU  - Delius H
FAU - Massague, J
AU  - Massague J
FAU - Niehrs, C
AU  - Niehrs C
LA  - eng
SI  - GENBANK/AJ243576
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (BAMBI protein, human)
RN  - 0 (BMP4 protein, human)
RN  - 0 (Bambi protein, mouse)
RN  - 0 (Bmp4 protein, mouse)
RN  - 0 (Bone Morphogenetic Protein 4)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Xenopus Proteins)
RN  - 0 (bambi-A protein, Xenopus)
RN  - 0 (bmp4 protein, Xenopus)
RN  - 104625-48-1 (Activins)
RN  - 57285-09-3 (Inhibins)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type I)
SB  - IM
MH  - Activins
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone Morphogenetic Protein 4
MH  - Bone Morphogenetic Protein Receptors, Type I
MH  - Bone Morphogenetic Proteins/antagonists & inhibitors/metabolism
MH  - COS Cells
MH  - Culture Techniques
MH  - Embryo, Nonmammalian/metabolism
MH  - Gene Expression
MH  - Humans
MH  - Inhibins/antagonists & inhibitors/metabolism
MH  - Ligands
MH  - Membrane Proteins/chemistry/genetics/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein-Serine-Threonine Kinases/chemistry
MH  - Receptors, Growth Factor/chemistry
MH  - Receptors, Transforming Growth Factor beta/metabolism
MH  - Sequence Homology
MH  - *Signal Transduction
MH  - Transforming Growth Factor beta/*metabolism
MH  - Tumor Cells, Cultured
MH  - Xenopus
MH  - *Xenopus Proteins
EDAT- 1999/10/16 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/10/16 09:00
PHST- 1999/10/16 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/10/16 09:00 [entrez]
AID - 10.1038/46794 [doi]
PST - ppublish
SO  - Nature. 1999 Sep 30;401(6752):480-5. doi: 10.1038/46794.