PMID- 10519157
OWN - NLM
STAT- MEDLINE
DCOM- 19991124
LR  - 20131121
IS  - 1081-650X (Print)
IS  - 1081-650X (Linking)
VI  - 111
IP  - 5
DP  - 1999 Sep-Oct
TI  - Myeloperoxidase.
PG  - 383-9
AB  - Phagocytes respond to stimulation with a burst of oxygen consumption, and much,
      if not all, of the extra oxygen consumed in the respiratory burst is converted
      first to the superoxide anion and then to hydrogen peroxide (H2O2).
      Myeloperoxidase (MPO), which is released from cytoplasmic granules of neutrophils
      and monocytes by a degranulation process, reacts with the H2O2 formed by the
      respiratory burst to form a complex that can oxidize a large variety of
      substances. Among the latter is chloride, which is oxidized initially to
      hypochlorous acid, with the subsequent formation of chlorine and chloramines.
      These products of the MPO-H2O2-chloride system are powerful oxidants that can
      have profound biological effects. The primary function of neutrophils is the
      phagocytosis and destruction of microorganisms, and the release of MPO and H2O2
      into the phagosome containing the ingested microorganism generally leads to a
      rapid microbicidal effect. Neutrophils from patients with chronic granulomatous
      disease (CGD) have a microbicidal defect that is associated with the absence of a
      respiratory burst and, thus, H2O2 production. Neutrophils from patients with a
      hereditary MPO deficiency, who lack MPO, also have a microbicidal defect,
      although it is not as severe as that seen in CGD. MPO and H2O2 also can be
      released to the outside of the cell where a reaction with chloride can induce
      damage to adjacent tissue and, thus, contribute to the pathogenesis of disease.
      It has been suggested that pulmonary injury, renal glomerular damage, and the
      initiation of atherosclerotic lesions may be caused by the MPO system.
FAU - Klebanoff, S J
AU  - Klebanoff SJ
AD  - Department of Medicine, University of Washington, Seattle 98195-7185, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Proc Assoc Am Physicians
JT  - Proceedings of the Association of American Physicians
JID - 9514310
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Blood Bactericidal Activity
MH  - Granulomatous Disease, Chronic/enzymology/immunology
MH  - Humans
MH  - Hydrogen Peroxide/metabolism
MH  - Neutrophils/enzymology/immunology/metabolism
MH  - Peroxidase/deficiency/*metabolism
MH  - Respiratory Burst
RF  - 61
EDAT- 1999/10/16 00:00
MHDA- 1999/10/16 00:01
CRDT- 1999/10/16 00:00
PHST- 1999/10/16 00:00 [pubmed]
PHST- 1999/10/16 00:01 [medline]
PHST- 1999/10/16 00:00 [entrez]
PST - ppublish
SO  - Proc Assoc Am Physicians. 1999 Sep-Oct;111(5):383-9.