PMID- 10518217
OWN - NLM
STAT- MEDLINE
DCOM- 19991029
LR  - 20061115
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 3
DP  - 1999 Sep
TI  - A novel cofactor for p300 that regulates the p53 response.
PG  - 365-76
AB  - The ability of p53 to function as a transcription factor is instrumental in
      facilitating the response to cellular stress, and p300/CBP proteins, which act as
      coactivators for diverse transcription factors, participate in regulating p53
      activity. We report a novel cofactor for p300 that facilitates the p53 response
      by augmenting p53-dependent transcription and apoptosis. JMY and p300 associate
      in physiological conditions, and, during the cellular stress response, the
      p300/JMY complex is recruited to activated p53. The bax gene is efficiently
      activated by JMY, and protein isoforms that arise through alternative splicing
      alter the functional outcome of the p53 response. The results provide compelling 
      evidence that the p300/JMY coactivator complex plays a central role in
      facilitating the p53 response.
FAU - Shikama, N
AU  - Shikama N
AD  - Division of Biochemistry and Molecular Biology, University of Glasgow, United
      Kingdom.
FAU - Lee, C W
AU  - Lee CW
FAU - France, S
AU  - France S
FAU - Delavaine, L
AU  - Delavaine L
FAU - Lyon, J
AU  - Lyon J
FAU - Krstic-Demonacos, M
AU  - Krstic-Demonacos M
FAU - La Thangue, N B
AU  - La Thangue NB
LA  - eng
SI  - GENBANK/AF201390
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (BAX protein, human)
RN  - 0 (JMY protein, human)
RN  - 0 (Jmy protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Trans-Activators)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (bcl-2-Associated X Protein)
SB  - IM
MH  - *Apoptosis
MH  - Cell Transformation, Neoplastic
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Gene Expression Regulation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Precipitin Tests
MH  - Protein Binding
MH  - Protein Isoforms/metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - *Proto-Oncogene Proteins c-bcl-2
MH  - Trans-Activators/genetics/*metabolism
MH  - Transcription, Genetic
MH  - Tumor Suppressor Protein p53/*metabolism
MH  - Two-Hybrid System Techniques
MH  - bcl-2-Associated X Protein
EDAT- 1999/10/13 00:00
MHDA- 1999/10/13 00:01
CRDT- 1999/10/13 00:00
PHST- 1999/10/13 00:00 [pubmed]
PHST- 1999/10/13 00:01 [medline]
PHST- 1999/10/13 00:00 [entrez]
AID - S1097-2765(00)80338-X [pii]
PST - ppublish
SO  - Mol Cell. 1999 Sep;4(3):365-76.