PMID- 10518211
OWN - NLM
STAT- MEDLINE
DCOM- 19991029
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 4
IP  - 3
DP  - 1999 Sep
TI  - Identification of the major intestinal fatty acid transport protein.
PG  - 299-308
AB  - While intestinal transport systems for metabolites such as carbohydrates have
      been well characterized, the molecular mechanisms of fatty acid (FA) transport
      across the apical plasmalemma of enterocytes have remained largely unclear. Here,
      we show that FATP4, a member of a large family of FA transport proteins (FATPs), 
      is expressed at high levels on the apical side of mature enterocytes in the small
      intestine. Further, overexpression of FATP4 in 293 cells facilitates uptake of
      long chain FAs with the same specificity as enterocytes, while reduction of FATP4
      expression in primary enterocytes by antisense oligonucleotides inhibits FA
      uptake by 50%. This suggests that FATP4 is the principal fatty acid transporter
      in enterocytes and may constitute a novel target for antiobesity therapy.
FAU - Stahl, A
AU  - Stahl A
AD  - Whitehead Institute for Biomedical Research, 9 Cambridge Center, Massachusetts
      02142, USA.
FAU - Hirsch, D J
AU  - Hirsch DJ
FAU - Gimeno, R E
AU  - Gimeno RE
FAU - Punreddy, S
AU  - Punreddy S
FAU - Ge, P
AU  - Ge P
FAU - Watson, N
AU  - Watson N
FAU - Patel, S
AU  - Patel S
FAU - Kotler, M
AU  - Kotler M
FAU - Raimondi, A
AU  - Raimondi A
FAU - Tartaglia, L A
AU  - Tartaglia LA
FAU - Lodish, H F
AU  - Lodish HF
LA  - eng
GR  - 5 T32 CA 09541/CA/NCI NIH HHS/United States
GR  - DK 47618/DK/NIDDK NIH HHS/United States
GR  - HL41484/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Carrier Proteins)
RN  - 0 (Fatty Acid Transport Proteins)
RN  - 0 (Fatty Acids)
RN  - 0 (Membrane Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Palmitates)
RN  - 0 (SLC27A4 protein, human)
RN  - 0 (Slc27a4 protein, mouse)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Binding, Competitive
MH  - Biological Transport
MH  - Carrier Proteins/genetics/*isolation & purification/metabolism
MH  - Cell Polarity
MH  - Enterocytes/*metabolism/ultrastructure
MH  - Fatty Acid Transport Proteins
MH  - Fatty Acids/*metabolism
MH  - Humans
MH  - Intestine, Small/*metabolism/ultrastructure
MH  - Membrane Proteins/genetics/*isolation & purification/metabolism
MH  - *Membrane Transport Proteins
MH  - Methionine/metabolism
MH  - Microvilli/chemistry/ultrastructure
MH  - Oleic Acid/metabolism
MH  - Oligonucleotides, Antisense
MH  - Palmitates/metabolism
MH  - Substrate Specificity
EDAT- 1999/10/13 00:00
MHDA- 1999/10/13 00:01
CRDT- 1999/10/13 00:00
PHST- 1999/10/13 00:00 [pubmed]
PHST- 1999/10/13 00:01 [medline]
PHST- 1999/10/13 00:00 [entrez]
AID - S1097-2765(00)80332-9 [pii]
AID - 10.1016/s1097-2765(00)80332-9 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Sep;4(3):299-308. doi: 10.1016/s1097-2765(00)80332-9.