PMID- 10518011
OWN - NLM
STAT- MEDLINE
DCOM- 19991124
LR  - 20211203
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 459
IP  - 2
DP  - 1999 Oct 8
TI  - A human homolog of Drosophila warts tumor suppressor, h-warts, localized to
      mitotic apparatus and specifically phosphorylated during mitosis.
PG  - 159-65
AB  - We identified a human homolog of Drosophila warts tumor suppressor gene, termed
      h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a
      serine/threonine kinase domain and is localized to centrosomes in interphase
      cells. However, it becomes localized to the mitotic apparatus, including spindle 
      pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during
      mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic 
      phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions 
      as a component of the mitotic apparatus and is involved in proper progression of 
      mitosis.
FAU - Nishiyama, Y
AU  - Nishiyama Y
AD  - Department of Tumor Genetics and Biology, Kumamoto University School of Medicine,
      2-2-1 Honjo, Kumamoto, Japan.
FAU - Hirota, T
AU  - Hirota T
FAU - Morisaki, T
AU  - Morisaki T
FAU - Hara, T
AU  - Hara T
FAU - Marumoto, T
AU  - Marumoto T
FAU - Iida, S
AU  - Iida S
FAU - Makino, K
AU  - Makino K
FAU - Yamamoto, H
AU  - Yamamoto H
FAU - Hiraoka, T
AU  - Hiraoka T
FAU - Kitamura, N
AU  - Kitamura N
FAU - Saya, H
AU  - Saya H
LA  - eng
SI  - GENBANK/AF164041
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Drosophila Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (LATS1 protein, human)
RN  - EC 2.7.1.- (wts protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - COS Cells
MH  - Cell Cycle/physiology
MH  - Cell Cycle Proteins/genetics/physiology
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 6
MH  - Drosophila/genetics
MH  - *Drosophila Proteins
MH  - Genes, Tumor Suppressor/physiology
MH  - HeLa Cells
MH  - Humans
MH  - Mitosis/*physiology
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - *Protein Kinases
MH  - Protein Serine-Threonine Kinases/chemistry
MH  - Sequence Homology, Amino Acid
MH  - Spindle Apparatus/*metabolism
EDAT- 1999/10/13 00:00
MHDA- 1999/10/13 00:01
CRDT- 1999/10/13 00:00
PHST- 1999/10/13 00:00 [pubmed]
PHST- 1999/10/13 00:01 [medline]
PHST- 1999/10/13 00:00 [entrez]
AID - S0014579399012247 [pii]
AID - 10.1016/s0014-5793(99)01224-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Oct 8;459(2):159-65. doi: 10.1016/s0014-5793(99)01224-7.